dot-ScoreCurve: CSS Facilitate Function - .ScoreCurve for Curves Fitted by...

Description Usage Arguments Value Author(s)

Description

New function used to score sensitivities given either a single-agent or a fixed conc (combination) columns. The function calculates the AUC of the log10-scaled dose-response curve. IMPORTANT: note that with LL.4 calls, this value is already logged since the input concentrations are logged.

Usage

1
.ScoreCurve(b, c, d, m, c1, c2, t)

Arguments

b

A numeric value, fitted parameter b from LL.4 model.

c

A numeric value, fitted parameter c from LL.4 model.

d

A numeric value, fitted parameter d from LL.4 model.

m

A numeric value, relative IC50 for the curve. log10(e), where e is the fitted parameter e from LL.4 model.

c1

A numeric value, log10(min conc) (this is the minimal nonzero concentration).

c2

A numeric value, log10(max conc) (this is the maximal concentration).

t

A numeric value, threshold (usually set to zero).

Value

A numeric value, RI or CSS scores.

Author(s)


synergyfinder documentation built on April 4, 2021, 6 p.m.