Plot2DrugContour: 2D Contour Plot for 2-drug Combination Dose-Response/Synergy...

In synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

This function will generate a contour level plot for 2-drug combinations. The axes are the dosage for each drug. The values could be observed response, synergy scores or the reference effects calculated from different models.

Usage

Plot2DrugContour(
  data,
  plot_block = 1,
  drugs = c(1, 2),
  plot_value = "response",
  interpolate_len = 2,
  summary_statistic = NULL,
  dynamic = FALSE,
  plot_title = NULL,
  col_range = NULL,
  row_range = NULL,
  high_value_color = "#A90217",
  low_value_color = "#2166AC",
  text_size_scale = 1
)

Arguments

data	A list object generated by function ReshapeData.
plot_block	A character/integer. It indicates the block ID for the block to visualize.
drugs	A vector of characters or integers with length of 2. It contains the index for two drugs to plot. For example, c(1, 2) indicates to plot "drug1" and "drug2" in the input data.
plot_value	A character value. It indicates the score or response value to be visualized. If the data is the direct output from ReshapeData, the available values for this parameter are: response_origin The original response value in input data. It might be % inhibition or % viability. response The % inhibition after preprocess by function ReshapeData If the data is the output from CalculateSynergy, following values are also available: ZIP_ref, Bliss_ref, HSA_ref, Loewe_ref The reference additive effects predicted by ZIP, Bliss, HSA or Loewe model, respectively. ZIP_synergy, Bliss_synergy, HSA_synergy, Loewe_synergy The synergy score calculated by ZIP, Bliss, HSA or Loewe model, respectively. ZIP_fit The response fitted by ZIP model.
interpolate_len	An integer. It specifies how many values need to be interpolated between two concentrations. It is used to control the smoothness of the synergy surface.
summary_statistic	A vector of characters or NULL. It indicates the summary statistics for all the plot_value in whole combination matrix. Available values are: mean Median value for all the responses or synergy scores in the matrix; median Median value for all the responses or synergy scores in the matrix; quantile_90 90% quantile. User could change the number to print different sample quantile. For example quantile_50 equal to median. If it is NULL, no statistics will be printed.
dynamic	A logical value. If it is TRUE, this function will use plot_ly to generate an interactive plot. If it is FALSE, this function will use wireframe to generate a static plot.
plot_title	A character value. It specifies the plot title. If it is NULL, the function will automatically generate a title.
col_range	A vector of two integers. They specify the starting and ending concentration of the drug on x-axis. Use e.g., c(1, 3) to specify that only from 1st to 3rd concentrations of the drug on x-axis are used. By default, it is NULl so all the concentrations are used.
row_range	A vector of two integers. They specify the starting and ending concentration of the drug on y-axis. Use e.g., c(1, 3) to specify that only from 1st to 3rd concentrations of the drug on y-axis are used. By default, it is NULl so all the concentrations are used.
high_value_color	An R color value. It indicates the color for the high values.
low_value_color	An R color value. It indicates the color for low values.
text_size_scale	A numeric value. It is used to control the size of text in the plot. All the text size will multiply by this scale factor.

Value

If dynamic = FALSE, this function will return a plot project recorded by recordPlot. If dynamic = FALSE, this function will return a plotly plot object.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
Plot2DrugContour(data)

synergyfinder documentation built on April 4, 2021, 6 p.m.