Loewe calculates the synergy score matrix from a dose-response matrix
by using a druginteraction reference model introduced by Loewe in 1953.
A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.
The expected minimum response value in the 4 parameter log-logistic model.
The expected maximum response value in the 4 parameter log-logistic model.
A logical value. If it is
Loewe model is a reference model for evaluating the combination
effect of two drugs. The basic assumption of this model is "The referece
effect of drug combination is the expected effect of a drug combined with
The optional arguments
designed for reuse the single drug dose response model fitting results,
if it has been down before. Functions
ExtractSingleDrug could be used to calculate these arguments.
A data frame containing the concentrations for drugs, reference effect and synergy score estimated by Loewe model.
Yadav B, Wennerberg K, Aittokallio T, Tang J.(2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.Comput Struct Biotechnol J, 13:504– 513.
[Loewe, 1953] Loewe, S. (1953). The problem of synergism and antagonism of combined drugs. Arzneimittelforschung, 3(6):285–290.
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