# Synergy score based on Bliss model

### Description

A function to calculate synergy score based on Bliss model

### Usage

1 2 |

### Arguments

`response.mat` |
a dose-response matrix with concentrations as row names and column names |

`correction` |
a parameter to specify if baseline correction is used or not. Defaults to TRUE. |

`Emin` |
the minimal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA. It is used only when correction is required. |

`Emax` |
the maximal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA. It is used only when correction is required. |

`nan.handle` |
a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs. |

### Value

A matrix of Bliss synergy scores for all the dose pairs for a drug combination. For a does pair with at least one zero concentration, 0 is used as the synergy score.

### Author(s)

Liye He liye.he@helsinki.fi

### References

Yadav B, Wennerberg K, Aittokallio T, Tang J. Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model. Computational and Structural Biotechnology Journal 2015; 13: 504-513.

### Examples

1 2 3 | ```
data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
delta.score <- Bliss(data$dose.response.mats[[1]])
``` |