Bliss: Calculate Bliss Synergy Score

In synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

Bliss calculates the synergy score matrix for a block of drug combination by using a drug interaction reference model introduced by C. I. Bliss in 1939.

Usage

Bliss(response, single_drug_data)

Arguments

response	A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.
single_drug_data	A list or NULL. It contains the monotherapy dose response data for all the tested drugs in the inputted block. If it is NULL, the data will extract the dose response table from inputted response table.

Details

This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The expected effect of two drugs acting independently". The Bliss reference effect y = 1 - product_all_drug(1-%Inhibition) * 100.

Value

A data frame containing the concentrations for drugs, reference effect and synergy score estimated by Bliss model.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

References

• Yadav B, Wennerberg K, Aittokallio T, Tang J. (2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model. Comput Struct Biotechnol J, 13:504– 513.

• Bliss, C. I. (1939). The toxicity of poisons applied jointly. Annals of Applied Biology, 26(3):585–615.

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response <- data$response[data$response$block_id == 1,
                          c("conc1", "conc2", "response")]
Bliss.score <- Bliss(response)

synergyfinder documentation built on April 4, 2021, 6 p.m.