ExtractSingleDrug: Extract Single Drug Dose Response

In synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

ExtractSingleDrug extracts the dose-response values of single drug from a drug combination dose-response matrix.

Usage

ExtractSingleDrug(response)

Arguments

response

A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.

Value

A list contains several data frames each of which contains 2 columns:

• dose The concertration of drug.

• response The cell's response (inhibation rate) to corresponding drug concertration.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response <- data$response[data$response$block_id == 1,
                          c("conc1", "conc2", "response")]
single <- ExtractSingleDrug(response)

synergyfinder documentation built on April 4, 2021, 6 p.m.