HSA calculates the synergy score matrix for a block of
drug combination by using Highest Single Agent (HSA) reference model.
A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.
This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The reference effect of drug combination is the maximal single drug effect".
A data frame containing the concentrations for drugs, reference effect and synergy score estimated by HSA model.
Yadav B, Wennerberg K, Aittokallio T, Tang J.(2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.Comput Struct Biotechnol J, 13:504– 513.
Berenbaum MC. (1989). What is synergy? Pharmacol Rev 1990 Sep;41(3):422.
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