get_biomarker_tables: Get True Biomarker Values on Training, Validation and Test...

In ICBioMark: Data-Driven Design of Targeted Gene Panels for Estimating Immunotherapy Biomarkers

Description

A function, similar to get_mutation_tables(), but returning the true biomarker values for a training, validation and test sets.

Usage

get_biomarker_tables(
  maf,
  biomarker = "TIB",
  sample_list = NULL,
  gene_list = NULL,
  biomarker_name = NULL,
  tables = NULL,
  split = c(train = 0.7, val = 0.15, test = 0.15),
  seed_id = 1234
)

Arguments

maf	(dataframe) A table of annotated mutations containing the columns 'Tumor_Sample_Barcode', 'Hugo_Symbol', and 'Variant_Classification'.
biomarker	(character) Which biomarker needs calculating? If "TMB" or "TIB", then appropriate mutation types will be selected. Otherwise, will be interpreted as a vector of characters denoting mutation types to include.
sample_list	(character) Vector of characters giving a list of values of Tumor_Sample_Barcode to include.
gene_list	(character) Vector of characters giving a list of genes to include in calculation of biomarker.
biomarker_name	(character) Name of biomarker. Only needed if biomarker is not "TMB" or "TIB"
tables	(list) Optional parameter, the output of a call to get_mutation_tables(), which already has a train/val/test split.
split	(numeric) Optional parameter directly specifying the proportions of a train/test/val split.
seed_id	(numeric) Input value for the function set.seed().

Value

A list of three objects: 'train', 'val' and 'test. Each comprises a dataframe with two columns, denoting sample ID and biomarker value.

Examples

print(head(get_biomarker_tables(example_maf_data$maf, sample_list = paste0("SAMPLE_", 1:100))))

ICBioMark documentation built on Nov. 15, 2021, 5:09 p.m.