METRADISC: Wrapper function for METRADISC method

In MAMA: Meta-Analysis of MicroArray

Description

This is a wrapper function for meta-analytical method called METRADISC that perform all steps of the analysis and return all the outputs in one line.

Usage

METRADISC(data, varname, nperm = 1000)

Arguments

data	MetaArray object
varname	Character String - name of one column in clinical data matrices to be used as class labels
nperm	Number of permutations for Monte Carlo permutation test, at least 1000 is suggested

Value

An object of class METRADISC.res containing

ranks	Ranks of the genes in each dataset
RQ	Average rank (R) and measure of heterogeneity (Q) for each gene
MCtest	Four p-values (for low and high R and low and high Q) for each gene as provided after Monte Carlo permutation test

Author(s)

Ivana Ihnatova

References

Zintzaras, E., Ioannidis, J.P.A 2008 Meta-analysis for ranked discovery datasets: Theoretical framework and empirical demonstration for microarrays, Computational Biology and Chemistry 32, 39-47

Examples

data(ColonData)
m <- METRADISC(ColonData, "MSI", 5)

MAMA documentation built on Jan. 15, 2017, 3:05 p.m.