PKNCAdata: Create a PKNCAdata object.

In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Create a PKNCAdata object.

Description

PKNCAdata combines PKNCAconc and PKNCAdose and adds in the intervals for PK calculations.

Usage

PKNCAdata(data.conc, data.dose, ...)

## S3 method for class 'PKNCAconc'
PKNCAdata(data.conc, data.dose, ...)

## S3 method for class 'PKNCAdose'
PKNCAdata(data.conc, data.dose, ...)

## Default S3 method:
PKNCAdata(
  data.conc,
  data.dose,
  ...,
  formula.conc,
  formula.dose,
  impute = NA_character_,
  intervals,
  units,
  options = list()
)

Arguments

data.conc	Concentration data as a PKNCAconc object or a data frame
data.dose	Dosing data as a PKNCAdose object (see details)
...	arguments passed to PKNCAdata.default
formula.conc	Formula for making a PKNCAconc object with data.conc. This must be given if data.conc is a data.frame, and it must not be given if data.conc is a PKNCAconc object.
formula.dose	Formula for making a PKNCAdose object with data.dose. This must be given if data.dose is a data.frame, and it must not be given if data.dose is a PKNCAdose object.
impute	Methods for imputation. NA for no imputation, a comma-or space-separated list of names, or the name of a column in the intervals data.frame. See vignette("v08-data-imputation", package="PKNCA") for more details.
intervals	A data frame with the AUC interval specifications as defined in check.interval.specification. If missing, this will be automatically chosen by choose.auc.intervals. (see details)
units	A data.frame of unit assignments and conversions as created by pknca_units_table()
options	List of changes to the default PKNCA.options for calculations.

Details

If data.dose is not given or is NA, then the intervals must be given. At least one of data.dose and intervals must be given.

Value

A PKNCAdata object with concentration, dose, interval, and calculation options stored (note that PKNCAdata objects can also have results after a NCA calculations are done to the data).

See Also

choose.auc.intervals, pk.nca, pknca_units_table()

Other PKNCA objects: PKNCAconc(), PKNCAdose(), PKNCAresults()

PKNCA documentation built on April 30, 2023, 1:08 a.m.