pk.calc.auciv: Calculate AUC for intravenous dosing

In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Calculate AUC for intravenous dosing

Description

Calculate AUC for intravenous dosing

Usage

pk.calc.auciv(conc, time, c0, auc, ..., check = TRUE)

pk.calc.auciv_pbext(auc, auciv)

Arguments

conc	Measured concentrations
time	Time of the measurement of the concentrations
c0	The concentration at time 0, typically calculated using pk.calc.c0()
auc	The AUC calculated using conc and time without c0 (it may be calculated using any method)
...	For functions other than pk.calc.auxc, these values are passed to pk.calc.auxc
check	Run assert_conc_time(), clean.conc.blq(), and clean.conc.na()?
auciv	The AUC calculated using c0

Details

The AUC for intravenous (IV) dosing extrapolates the AUC back from the first measurement to time 0 using c0 and the AUC calculated by another method (for example the auclast).

The calculation method takes the following steps:

• time = 0 must be present in the data with a measured concentration.

• The AUC between time = 0 and the next time point is calculated (auc_first).

• The AUC between time = 0 with c0 and the next time point is calculated (auc_second).

• The final AUC is the initial AUC plus the difference between the two AUCs (auc_final <- auc + auc_second - auc_first).

The calculation for back-extrapolation is 100*(1 - auc/auciv).

Value

pk.calc.auciv: The AUC calculated using c0

pk.calc.auciv_pctbackextrap: The AUC percent back-extrapolated

Functions

• pk.calc.auciv_pbext(): Calculate the percent back-extrapolated AUC for IV administration

PKNCA documentation built on June 22, 2024, 9:25 a.m.