pk.calc.time_above: Determine time at or above a set value

In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Determine time at or above a set value

Description

Interpolation is performed aligning with PKNCA.options("auc.method"). Extrapolation outside of the measured times is not yet implemented. The method may be changed by giving a named method argument, as well.

Usage

pk.calc.time_above(conc, time, conc_above, ..., options = list(), check = TRUE)

Arguments

conc	Concentration measured
time	Time of concentration measurement (must be monotonically increasing and the same length as the concentration data)
conc_above	The concentration to be above
...	Extra arguments. Currently, the only extra argument that is used is method as described in the details section.
options	List of changes to the default PKNCA.options for calculations.
check	Run check.conc.time, clean.conc.blq, and clean.conc.na?

Details

For 'lin up/log down', if clast is above conc_above and there are concentrations BLQ after that, linear down is used to extrapolate to the BLQ concentration (equivalent to AUCall).

Value

the time above the given concentration

PKNCA documentation built on April 30, 2023, 1:08 a.m.