pk.nca.interval: Compute all PK parameters for a single concentration-time...

Description Usage Arguments Value See Also

View source: R/pk.calc.all.R

Description

For one subject/time range, compute all available PK parameters. All the internal options should be set by PKNCA.options prior to running. The only part that changes with a call to this function is the concentration and time.

Usage

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pk.nca.interval(conc, time, volume, duration.conc, dose, time.dose,
  duration.dose, route, conc.group = NULL, time.group = NULL,
  volume.group = NULL, duration.conc.group = NULL, dose.group = NULL,
  time.dose.group = NULL, duration.dose.group = NULL, route.group = NULL,
  include_half.life = NULL, exclude_half.life = NULL, interval,
  options = list())

Arguments

conc, conc.group

Concentration measured for the current interval or all data for the group

time, time.group

Time of concentration measurement for the current interval or all data for the group

volume, volume.group

The volume (or mass) of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)

duration.conc, duration.conc.group

The duration of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)

dose, dose.group

Dose amount (may be a scalar or vector) for the current interval or all data for the group

time.dose, time.dose.group

Time of the dose for the current interval or all data for the group (must be the same length as dose or dose.group)

duration.dose, duration.dose.group

The duration of the dose administration for the current interval or all data for the group (typically zero for extravascular and intravascular bolus and nonzero for intravascular infusion)

route, route.group

The route of dosing for the current interval or all data for the group

include_half.life

An optional boolean vector of the concentration measurements to include in the half-life calculation. If given, no half-life point selection will occur.

exclude_half.life

An optional boolean vector of the concentration measurements to exclude from the half-life calculation.

interval

One row of an interval definition (see check.interval.specification for how to define the interval.

options

List of changes to the default PKNCA.options for calculations.

Value

A data frame with the start and end time along with all PK parameters for the interval

See Also

check.interval.specification


PKNCA documentation built on Jan. 4, 2018, 4:04 a.m.