pk.nca.interval: Compute all PK parameters for a single concentration-time...
In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

pk.nca.interval

R Documentation

Compute all PK parameters for a single concentration-time data set

Description

For one subject/time range, compute all available PK parameters. All the internal options should be set by PKNCA.options() prior to running. The only part that changes with a call to this function is the concentration and time.

Usage

pk.nca.interval(
  conc,
  time,
  volume,
  duration.conc,
  dose,
  time.dose,
  duration.dose,
  route,
  conc.group = NULL,
  time.group = NULL,
  volume.group = NULL,
  duration.conc.group = NULL,
  dose.group = NULL,
  time.dose.group = NULL,
  duration.dose.group = NULL,
  route.group = NULL,
  impute_method = NA_character_,
  include_half.life = NULL,
  exclude_half.life = NULL,
  subject,
  sparse,
  interval,
  options = list()
)

Arguments

`conc`	Measured concentrations
`time`	Time of the measurement of the concentrations
`volume`, `volume.group`	The volume (or mass) of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)
`duration.conc`, `duration.conc.group`	The duration of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)
`dose`, `dose.group`	Dose amount (may be a scalar or vector) for the current interval or all data for the group
`time.dose`, `time.dose.group`	Time of the dose for the current interval or all data for the group (must be the same length as `dose` or `dose.group`)
`duration.dose`, `duration.dose.group`	The duration of the dose administration for the current interval or all data for the group (typically zero for extravascular and intravascular bolus and nonzero for intravascular infusion)
`route`, `route.group`	The route of dosing for the current interval or all data for the group
`conc.group`	All concentrations measured for the group
`time.group`	Time of all concentrations measured for the group
`impute_method`	The method to use for imputation as a character string
`include_half.life`	An optional boolean vector of the concentration measurements to include in the half-life calculation. If given, no half-life point selection will occur.
`exclude_half.life`	An optional boolean vector of the concentration measurements to exclude from the half-life calculation.
`subject`	Subject identifiers (used for sparse calculations)
`sparse`	Should only sparse calculations be performed (TRUE) or only dense calculations (FALSE)?
`interval`	One row of an interval definition (see `check.interval.specification()` for how to define the interval.
`options`	List of changes to the default PKNCA options (see `PKNCA.options()`)