superposition: Compute noncompartmental superposition for repeated dosing
In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

superposition

R Documentation

Compute noncompartmental superposition for repeated dosing

Description

Compute noncompartmental superposition for repeated dosing

Usage

superposition(conc, ...)

## S3 method for class 'PKNCAconc'
superposition(conc, ...)

## S3 method for class 'numeric'
superposition(
  conc,
  time,
  dose.input = NULL,
  tau,
  dose.times = 0,
  dose.amount,
  n.tau = Inf,
  options = list(),
  lambda.z,
  clast.pred = FALSE,
  tlast,
  additional.times = numeric(),
  check.blq = TRUE,
  method = NULL,
  auc.type = "AUCinf",
  steady.state.tol = 0.001,
  ...
)

Arguments

`conc`	Measured concentrations
`...`	Additional arguments passed to the `half.life` function if required to compute `lambda.z`.
`time`	Time of the measurement of the concentrations
`dose.input`	The dose given to generate the `conc` and `time` inputs. If missing, output doses will be assumed to be equal to the input dose.
`tau`	The dosing interval
`dose.times`	The time of dosing within the dosing interval. The `min(dose.times)` must be >= 0, and the `max(dose.times)` must be < `tau`. There may be more than one dose times given as a vector.
`dose.amount`	The doses given for the output. Linear proportionality will be used from the input to output if they are not equal. The length of dose.amount must be either 1 or matching the length of `dose.times`.
`n.tau`	The number of tau dosing intervals to simulate or `Inf` for steady-state.
`options`	List of changes to the default PKNCA options (see `PKNCA.options()`)
`lambda.z`	The elimination rate (in units of inverse time) for extrapolation
`clast.pred`	To use predicted as opposed to observed Clast, either give the value for clast.pred here or set it to true (for automatic calculation from the half-life).
`tlast`	The time of last observed concentration above the limit of quantification. This is calculated if not provided.
`additional.times`	Times to include in the final outputs in addition to the standard times (see details). All `min(additional.times)` must be >= 0, and the `max(additional.times)` must be <= `tau`.
`check.blq`	Must the first concentration measurement be below the limit of quantification?
`method`	The method for integration (one of 'lin up/log down', 'lin-log', or 'linear')
`auc.type`	The type of AUC to compute. Choices are 'AUCinf', 'AUClast', and 'AUCall'.
`steady.state.tol`	The tolerance for assessing if steady-state has been achieved (between 0 and 1, exclusive).

Details

The returned superposition times will include all of the following times: 0 (zero), dose.times, ⁠time modulo tau⁠ (shifting time for each dose time as well), additional.times, and tau.