CVwRfromU | R Documentation |
Calculates the intra-subject CV (coefficient of variation) of the reference from the upper expanded limit of a BE study (replicate design for ABEL). Useful if no CV_{wR} but the expanded limits were given.
CVwRfromU(U, regulator = "EMA") U2CVwR(U, regulator = "EMA")
U |
Upper expanded limit. |
regulator |
Regulatory body’s settings for expanding the BE acceptance limits,
given as a string from the choices |
Only the upper expanded limit is supported since it offers one more significant digit than the lower expanded limit.
Numeric value of the CVwR
as ratio, where
CVwR = sqrt(exp((log(U)/r_const)^2)-1)
.
U2CVwR()
is simply an alias to CVwRfromU()
.
H. Schütz
# Given the upper expanded limit and using the defaults CVwRfromU(U = 1.38) # should give [1] 0.44355, i.e., a CVwR ~ 44% # Upper limit from a study according the Health Canada’s rules CVwRfromU(U = 1.48, regulator = "HC") # should give [1] 0.55214
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