Calculates the intra-subject CV (coefficient of variation) of the reference from the upper expanded limit of a BE study (replicate design for ABEL). Useful if no CVwR but the expanded limits were given.
CVwRfromU(U, regulator = "EMA") U2CVwR(U, regulator = "EMA")
Upper expanded limit.
Regulatory body’s settings for expanding the BE acceptance limits,
given as a string from the choices
Only the upper expanded limit is supported since it offers one more significant digit than the lower expanded limit.
Numeric value of the
CVwR as ratio, where
CVwR = sqrt(exp((log(U)/r_const)^2)-1).
U2CVwR() is simply an alias to
# Given the upper expanded limit and using the defaults CVwRfromU(U = 1.38) # should give  0.44355, i.e., a CVwR ~ 44% # Upper limit from a study according the Health Canada’s rules CVwRfromU(U = 1.48, regulator = "HC") # should give  0.55214
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