ctSJ.VIII.10+ctSJ.VIII.20+ctCW.III | R Documentation |
These data.frames give sample size tables calculated with
sampleN.TOST()
for the parallel group design (2 groups).
The data.frames can be accessed by their names.
data.frame | Description |
ctSJ.VIII.10 | Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), target power=90% |
approximate power via non-central t-distribution | |
ctSJ.VIII.20 | Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), target power=90% |
approximate power via non-central t-distribution | |
ctCW.III | Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20), exact |
Attention! Julious gives sample size per group.
Scripts for creation of these data.frames can be found in the /tests
sub-directory of the package.
Comparing the results of these scripts to the corresponding data.frames can
be used for validation purposes.
PowerTOST
data.frame | Origin | Details |
ctSJ.VIII.10 | Julious | Table VIII (p. 1972), column ‘Level of bioequivalence 10%’ |
ctSJ.VIII.20 | Julious | Table VIII (p. 1972), column ‘Level of bioequivalence 20%’ |
ctCW.III | Chow & Wang | Table III (p. 164) |
Seems the last reference is not very reliable (compare to the table in the paper).
Julious SA. Tutorial in Biostatistics. Sample sizes for clinical trials with Normal data. Stat Med. 2004;23(12):1921–86. doi: 10.1002/sim.1783
Chow SC, Wang H. On Sample Size Calculation in Bioequivalence Trials. J Pharmacokinet Pharmacodyn. 2001;28(2):155–69. doi: 10.1023/A:1011503032353
ctSJ.VIII.10 ctSJ.VIII.20 ctCW.III
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