Sample size tables for the parallel group design


These data.frames give sample size tables calculated with sampleN.TOST() for the parallel group design (2 groups).


The data.frame's can be accessed by their names or by data("name").

ctSJ.VIII.10 is Table VIII, column 'level of bioequivalence 10%' from
"Tutorial in Biostatistics
Sample sizes for clinical trials with Normal data"
'Statistics in Medicine, Vol. 23, 1921-1986 (2004)
Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), target power=90%,
power approximate via non-central t-distribution.
Attention! Julious gives sample size per group.

ctSJ.VIII.20 is Table VIII from the same source
column 'level of bioequivalence 20%'
Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), target power=90%,
power approximate via non-central t.

ctCW.III is Table III from
Chow and Wang
"On Sample Size Calculation in Bioequivalence Trials"
J. Pharmacokin. Biopharm. Vol. 28(2), 155-169 (2001)
Additive model, theta1=-0.2, theta2=+0.2 (BE limits 0.80 - 1.20), exact.

Seems the last reference is not very reliable (compare to the Table in the paper).


Scripts for creation of these data.frame's can be found in the \test sub-directory of the package.
Comparing the results of that scripts to the corresponding data.frames can be used for validation purposes.



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