data_parallel: Sample size tables for the parallel group design

Description Details Note Author(s)

Description

These data.frames give sample size tables calculated with sampleN.TOST() for the parallel group design (2 groups).

Details

The data.frame's can be accessed by their names or by data("name").

ctSJ.VIII.10 is Table VIII, column 'level of bioequivalence 10%' from
S.A.Julious
"Tutorial in Biostatistics
Sample sizes for clinical trials with Normal data"
'Statistics in Medicine, Vol. 23, 1921-1986 (2004)
Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), target power=90%,
power approximate via non-central t-distribution.
Attention! Julious gives sample size per group.

ctSJ.VIII.20 is Table VIII from the same source
column 'level of bioequivalence 20%'
Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), target power=90%,
power approximate via non-central t.

ctCW.III is Table III from
Chow and Wang
"On Sample Size Calculation in Bioequivalence Trials"
J. Pharmacokin. Biopharm. Vol. 28(2), 155-169 (2001)
Additive model, theta1=-0.2, theta2=+0.2 (BE limits 0.80 - 1.20), exact.

Seems the last reference is not very reliable (compare to the Table in the paper).

Note

Scripts for creation of these data.frame's can be found in the \test sub-directory of the package.
Comparing the results of that scripts to the corresponding data.frames can be used for validation purposes.

Author(s)

PowerTOST



Search within the PowerTOST package
Search all R packages, documentation and source code

Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

Please suggest features or report bugs with the GitHub issue tracker.

All documentation is copyright its authors; we didn't write any of that.