data_parallel: Sample Size Tables for the Parallel Group Design
In PowerTOST: Power and Sample Size for (Bio)Equivalence Studies

ctSJ.VIII.10+ctSJ.VIII.20+ctCW.III

R Documentation

Sample Size Tables for the Parallel Group Design

Description

These data.frames give sample size tables calculated with sampleN.TOST() for the parallel group design (2 groups).

Details

The data.frames can be accessed by their names.

data.frame	Description
ctSJ.VIII.10	Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), target power=90%
	approximate power via non-central t-distribution
ctSJ.VIII.20	Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), target power=90%
	approximate power via non-central t-distribution
ctCW.III	Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20), exact

Attention! Julious gives sample size per group.

Note

Scripts for creation of these data.frames can be found in the /tests sub-directory of the package.
Comparing the results of these scripts to the corresponding data.frames can be used for validation purposes.

Author(s)

PowerTOST

Source

data.frame	Origin	Details
ctSJ.VIII.10	Julious	Table VIII (p. 1972), column ‘Level of bioequivalence 10%’
ctSJ.VIII.20	Julious	Table VIII (p. 1972), column ‘Level of bioequivalence 20%’
ctCW.III	Chow & Wang	Table III (p. 164)

Seems the last reference is not very reliable (compare to the table in the paper).

References

Julious SA. Tutorial in Biostatistics. Sample sizes for clinical trials with Normal data. Stat Med. 2004;23(12):1921–86. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1002/sim.1783")}

Chow SC, Wang H. On Sample Size Calculation in Bioequivalence Trials. J Pharmacokinet Pharmacodyn. 2001;28(2):155–69. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1023/A:1011503032353")}