data_2x2: Sample Size Tables for the Classical 2x2 Crossover Design

Description Details Note Author(s) Source References Examples

Description

These data.frames give sample size tables calculated with sampleN.TOST() for the 2×2 design.

Details

The data.frames can be accessed by their names.

data.frame Description
ct5.1 Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), exact
ct5.2 Multiplicative model, theta1=0.75, theta2=1.3333 (1/theta1), exact
ct5.3 Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), exact
ct5.4.1 Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20), exact

Note

Scripts for creation of these data.frames can be found in the /test sub-directory of the package.
Comparing the results of these scripts to the corresponding data.frames can be used for validation purposes.

Author(s)

PowerTOST

Source

data.frame Origin Details
ct5.1 Hauschke et al. Table 5.1 (p 113--114)
ct5.2 Hauschke et al. Table 5.2 (p 115--116)
ct5.3 Hauschke et al. Table 5.3 (p 118)
ct5.4.1 Chow & Liu Table 5.4.1 (p 158)

References

Hauschke D, Steinijans VW, Pigeot I. Bioequivalence Studies in Drug Development. Chichester: John Wiley; 2007.

Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. Boca Raton: CRC Press; 3rd edition 2009.

Examples

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Example output

   power    CV R0.85 R0.9 R0.95 R1.0 R1.05 R1.1 R1.15 R1.2
1    0.8 0.100    36   12     8    6     8   10    20   76
2    0.8 0.125    54   16    10    8    10   14    30  118
3    0.8 0.150    78   22    12   10    12   20    42  168
4    0.8 0.175   104   30    16   14    16   26    56  226
5    0.8 0.200   134   38    20   16    18   32    72  294
6    0.8 0.225   168   46    24   20    24   40    90  368
7    0.8 0.250   206   56    28   24    28   48   110  452
8    0.8 0.275   248   68    34   28    34   58   132  544
9    0.8 0.300   292   80    40   32    38   68   156  642
10   0.8 0.325   340   92    46   36    44   78   180  748
11   0.8 0.350   392  106    52   42    50   90   208  860
12   0.8 0.375   446  120    58   48    58  102   236  978
13   0.8 0.400   502  134    66   54    64  114   266 1104
14   0.9 0.100    48   14     8    8     8   14    26  104
15   0.9 0.125    74   22    12   10    12   18    40  162
16   0.9 0.150   106   30    16   12    16   26    58  232
17   0.9 0.175   142   40    20   16    20   34    76  312
18   0.9 0.200   186   50    26   20    24   44   100  406
19   0.9 0.225   232   64    32   24    30   54   124  510
20   0.9 0.250   284   78    38   28    36   66   152  626
21   0.9 0.275   342   92    44   34    44   78   182  752
22   0.9 0.300   404  108    52   40    52   92   214  888
23   0.9 0.325   470  126    60   46    60  108   250 1034
24   0.9 0.350   540  146    70   52    68  124   288 1190
25   0.9 0.375   616  164    80   60    78  140   326 1354
26   0.9 0.400   694  186    88   66    86  158   368 1528
   power    CV R0.8 R0.85 R0.9 R0.95 R1.0 R1.05 R1.1 R1.15 R1.2 R1.25
1    0.8 0.150   68    20   10     8    8     8   10    16   28    68
2    0.8 0.175   92    26   14    10   10    10   12    20   36    92
3    0.8 0.200  118    34   18    12   10    12   16    24   46   118
4    0.8 0.225  148    42   20    14   12    14   20    30   58   148
5    0.8 0.250  182    50   26    16   16    16   22    36   70   182
6    0.8 0.275  218    60   30    20   18    20   26    44   84   218
7    0.8 0.300  258    70   34    22   20    22   32    52   98   258
8    0.8 0.325  300    82   40    26   24    26   36    60  114   300
9    0.8 0.350  346    94   46    30   26    30   42    68  132   346
10   0.8 0.375  392   106   52    34   30    34   46    76  148   392
11   0.8 0.400  442   120   58    38   34    36   52    86  168   442
12   0.8 0.425  496   134   64    42   36    42   58    96  188   496
13   0.8 0.450  550   148   72    46   40    46   64   106  208   550
14   0.9 0.150   94    26   14    10    8    10   12    20   36    94
15   0.9 0.175  126    36   18    12   10    12   16    26   48   126
16   0.9 0.200  164    46   22    14   12    14   20    34   62   164
17   0.9 0.225  206    56   28    18   16    18   26    42   78   206
18   0.9 0.250  252    68   34    22   18    22   30    50   96   252
19   0.9 0.275  302    82   40    26   22    24   36    60  114   302
20   0.9 0.300  356    96   46    30   26    28   42    70  136   356
21   0.9 0.325  416   112   54    34   28    34   48    80  158   416
22   0.9 0.350  478   128   62    38   32    38   56    92  180   478
23   0.9 0.375  544   146   70    44   36    42   64   106  206   544
24   0.9 0.400  612   164   78    48   42    48   72   118  232   612
25   0.9 0.425  686   184   88    54   46    54   80   132  258   686
26   0.9 0.450  760   204   98    60   50    60   88   146  286   760
   power    CV R0.925 R0.95 R0.975 R1.0 R1.025 R1.05 R1.075
1    0.8 0.050     44    14      8    6      8    12     30
2    0.8 0.075     94    26     14   12     14    24     66
3    0.8 0.100    166    44     22   18     22    40    116
4    0.8 0.125    258    68     32   26     32    62    178
5    0.8 0.150    368    96     46   36     46    88    254
6    0.8 0.175    500   130     62   48     62   118    344
7    0.8 0.200    648   168     80   62     78   154    446
8    0.8 0.225    816   212    100   78     98   194    562
9    0.8 0.250   1000   258    122   96    120   236    690
10   0.9 0.050     60    18     10    8     10    16     42
11   0.9 0.075    130    36     18   14     18    32     90
12   0.9 0.100    230    60     30   22     28    56    158
13   0.9 0.125    356    94     44   32     44    86    246
14   0.9 0.150    510   132     62   46     62   122    352
15   0.9 0.175    690   180     84   62     82   164    476
16   0.9 0.200    898   232    108   78    106   212    618
17   0.9 0.225   1130   292    134   98    132   266    778
18   0.9 0.250   1386   358    164  120    162   326    954
   power   CV R0.0 R0.05 R0.1 R0.15
1    0.8 0.10    8     8   14    52
2    0.8 0.12    8    10   20    74
3    0.8 0.14   12    14   26   100
4    0.8 0.16   14    16   34   128
5    0.8 0.18   16    20   42   162
6    0.8 0.20   20    24   52   200
7    0.8 0.22   24    30   62   242
8    0.8 0.24   28    34   74   288
9    0.8 0.26   32    40   86   336
10   0.8 0.28   36    46  100   390
11   0.8 0.30   40    52  114   448
12   0.8 0.32   46    60  128   508
13   0.8 0.34   52    66  146   574
14   0.8 0.36   58    74  162   644
15   0.8 0.38   64    84  180   716
16   0.8 0.40   70    92  200   794
17   0.9 0.10    8    10   20    70
18   0.9 0.12   10    14   28   102
19   0.9 0.14   14    18   36   136
20   0.9 0.16   16    22   46   178
21   0.9 0.18   20    28   58   224
22   0.9 0.20   24    32   70   276
23   0.9 0.22   28    40   86   334
24   0.9 0.24   34    46  102   396
25   0.9 0.26   40    54  118   466
26   0.9 0.28   44    62  136   540
27   0.9 0.30   52    72  156   618
28   0.9 0.32   58    80  178   704
29   0.9 0.34   64    90  200   794
30   0.9 0.36   72   102  224   890
31   0.9 0.38   80   112  250   992
32   0.9 0.40   88   124  276  1098

PowerTOST documentation built on Jan. 18, 2021, 5:07 p.m.