data_2x2: Sample Size Tables for the Classical 2x2 Crossover Design

In PowerTOST: Power and Sample Size for (Bio)Equivalence Studies

Sample Size Tables for the Classical 2x2 Crossover Design

Description

These data.frames give sample size tables calculated with sampleN.TOST() for the 2×2 design.

Details

The data.frames can be accessed by their names.

data.frame	Description
ct5.1	Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), exact
ct5.2	Multiplicative model, theta1=0.75, theta2=1.3333 (1/theta1), exact
ct5.3	Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), exact
ct5.4.1	Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20), exact

Note

Scripts for creation of these data.frames can be found in the /tests sub-directory of the package.
Comparing the results of these scripts to the corresponding data.frames can be used for validation purposes.

Author(s)

PowerTOST

Source

data.frame	Origin	Details
ct5.1	Hauschke et al.	Table 5.1 (p 113--114)
ct5.2	Hauschke et al.	Table 5.2 (p 115--116)
ct5.3	Hauschke et al.	Table 5.3 (p 118)
ct5.4.1	Chow & Liu	Table 5.4.1 (p 158)

References

Hauschke D, Steinijans VW, Pigeot I. Bioequivalence Studies in Drug Development. Chichester: John Wiley; 2007.

Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. Boca Raton: CRC Press; 3^rd edition 2009.

Examples

ct5.1
ct5.2
ct5.3
ct5.4.1

PowerTOST documentation built on May 29, 2024, 4:40 a.m.