analyze_gene_drug_response_asso: Analyze Association between Gene (Signature) and Drug...
In UCSCXenaShiny: Interactive Analysis of UCSC Xena Data

View source: R/analyze_gene_drug_response.R

analyze_gene_drug_response_asso

R Documentation

Analyze Association between Gene (Signature) and Drug Response with CCLE Data

Description

Analyze partial correlation of gene-drug association after controlling for tissue average expression.

Usage

analyze_gene_drug_response_asso(gene_list, combine = FALSE)

Arguments

`gene_list`	a gene symbol list.
`combine`	if `TRUE`, combine the expression of gene list as a gene signature.

Value

a data.frame

If combine is TRUE, genes are combined as signature.
mean.diff and median.diff indicate mean and median of normalized expression difference between High IC50 cells and Low IC50 cells. The cutoff between High and Low are median IC50.

Examples

## Not run: 
analyze_gene_drug_response_asso("TP53")
analyze_gene_drug_response_asso(c("TP53", "KRAS"))
analyze_gene_drug_response_asso(c("TP53", "KRAS"), combine = TRUE)

# Visualization
vis_gene_drug_response_asso("TP53")

## End(Not run)

UCSCXenaShiny documentation built on Aug. 8, 2025, 7:19 p.m.