dyeBiasCorrMostBalanced: Correct dye bias using most balanced sample as the reference

In zwdzwd/sesame: SEnsible Step-wise Analysis of DNA MEthylation BeadChips

Correct dye bias using most balanced sample as the reference

Description

The function chose the reference signal level from a list of SigDF. The chosen sample has the smallest difference in Grn and Red signal intensity as measured using the normalization control probes. In practice, it doesn't matter which sample is chosen as long as the reference level does not deviate much. The function returns a list of SigDFs with dye bias corrected.

Usage

dyeBiasCorrMostBalanced(sdfs)

Arguments

sdfs	a list of normalized SigDFs

Value

a list of normalized SigDFs

Examples

sesameDataCache() # if not done yet
sdfs <- sesameDataGet('HM450.10.SigDF')[1:2]
sdfs.db <- dyeBiasCorrMostBalanced(sdfs)

zwdzwd/sesame documentation built on Dec. 21, 2024, 1:20 p.m.