inferSex: Infer sex.
In zwdzwd/sesame: SEnsible Step-wise Analysis of DNA MEthylation BeadChips

inferSex

R Documentation

Infer sex.

Description

We established our sex calling based on the CpGs hypermethylated in inactive X (XiH), CpGs hypomethylated in inactive X (XiL).

Usage

inferSex(betas, platform = NULL)

Arguments

`betas`	DNA methylation beta
`platform`	EPICv2, EPIC, HM450, MM285, etc.

Details

Note genotype abnormalities such as Dnmt genotype, XXY male (Klinefelter's), 45,X female (Turner's) can confuse the model sometimes. This function works on a single sample.

Value

Inferred sex of sample

Examples


## EPICv2 input
betas = openSesame(sesameDataGet("EPICv2.8.SigDF")[[1]])
inferSex(betas)

## Not run: 
## MM285 input
betas = openSesame(sesameDataGet("MM285.1.SigDF"))
inferSex(betas)

## EPIC input
betas = openSesame(sesameDataGet('EPIC.1.SigDF'))
inferSex(betas)

## HM450 input
betas = openSesame(sesameDataGet("HM450.10.SigDF")[[1]])
inferSex(betas)

## End(Not run)

zwdzwd/sesame documentation built on Nov. 11, 2024, 9:33 a.m.