RTN: RTN: Reconstruction of Transcriptional regulatory Networks and analysis of regulons

A transcriptional regulatory network (TRN) consists of a collection of transcription factors (TFs) and the regulated target genes. TFs are regulators that recognize specific DNA sequences and guide the expression of the genome, either activating or repressing the expression the target genes. The set of genes controlled by the same TF forms a regulon. This package provides classes and methods for the reconstruction of TRNs and analysis of regulons.

Package details

AuthorClarice Groeneveld [ctb], Gordon Robertson [ctb], Xin Wang [aut], Michael Fletcher [aut], Florian Markowetz [aut], Kerstin Meyer [aut], and Mauro Castro [aut]
Bioconductor views GeneExpression GeneRegulation GeneSetEnrichment GeneticVariability GraphAndNetwork Network NetworkEnrichment NetworkInference Transcription
MaintainerMauro Castro <mauro.a.castro@gmail.com>
URL http://dx.doi.org/10.1038/ncomms3464
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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RTN documentation built on Nov. 12, 2020, 2:02 a.m.