pk.calc.cl: Calculate the (observed oral) clearance
In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis
View source: R/pk.calc.simple.R
pk.calc.cl R Documentation
Calculate the (observed oral) clearance
Description
Calculate the (observed oral) clearance
Usage
pk.calc.cl(dose, auc)
Arguments
dose
the dose administered
auc
The area under the concentration-time curve.
Details
cl is dose/auc.
If dose is the same length as the other inputs, then the
output will be the same length as all of the inputs; the function assumes
that you are calculating for multiple intervals simultaneously. If the
inputs other than dose are scalars and dose is a vector, then
the function assumes multiple doses were given in a single interval, and
the sum of the doses will be used for the calculation.
Value
the numeric value of the total (CL) or observed oral clearance (CL/F)
References
Gabrielsson J, Weiner D. "Section 2.5.1 Derivation of clearance."
Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications,
4th Edition. Stockholm, Sweden: Swedish Pharmaceutical Press, 2000. 86-7.
PKNCA documentation built on April 30, 2023, 1:08 a.m.
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View source: R/pk.calc.simple.R
| pk.calc.cl | R Documentation |
Calculate the (observed oral) clearance
Description
Calculate the (observed oral) clearance
Usage
pk.calc.cl(dose, auc)
Arguments
dose |
the dose administered |
auc |
The area under the concentration-time curve. |
Details
cl is dose/auc.
If dose is the same length as the other inputs, then the
output will be the same length as all of the inputs; the function assumes
that you are calculating for multiple intervals simultaneously. If the
inputs other than dose are scalars and dose is a vector, then
the function assumes multiple doses were given in a single interval, and
the sum of the doses will be used for the calculation.
Value
the numeric value of the total (CL) or observed oral clearance (CL/F)
References
Gabrielsson J, Weiner D. "Section 2.5.1 Derivation of clearance." Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications, 4th Edition. Stockholm, Sweden: Swedish Pharmaceutical Press, 2000. 86-7.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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