var_sparse_auc: Calculate the variance for the AUC of sparsely sampled PK
In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis
var_sparse_auc R Documentation
Calculate the variance for the AUC of sparsely sampled PK
Description
Equation 7.vii in Nedelman and Jia, 1998 is used for this calculation:
Usage
var_sparse_auc(sparse_pk)
Arguments
sparse_pk
A sparse_pk object from as_sparse_pk()
Details
var\left(\hat{AUC}\right) = \sum\limits_{i=0}^m\left(\frac{w_i^2 s_i^2}{r_i}\right) + 2\sum\limits_{i<j}\left(\frac{w_i w_j r_{ij} s_{ij}}{r_i r_j}\right)
The degrees of freedom are calculated as described in equation 6 of the same
paper.
References
Nedelman JR, Jia X. An extension of Satterthwaite’s approximation applied to
pharmacokinetics. Journal of Biopharmaceutical Statistics. 1998;8(2):317-328.
doi:10.1080/10543409808835241
PKNCA documentation built on June 22, 2024, 9:25 a.m.
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| var_sparse_auc | R Documentation |
Calculate the variance for the AUC of sparsely sampled PK
Description
Equation 7.vii in Nedelman and Jia, 1998 is used for this calculation:
Usage
var_sparse_auc(sparse_pk)
Arguments
sparse_pk |
A sparse_pk object from |
Details
var\left(\hat{AUC}\right) = \sum\limits_{i=0}^m\left(\frac{w_i^2 s_i^2}{r_i}\right) + 2\sum\limits_{i<j}\left(\frac{w_i w_j r_{ij} s_{ij}}{r_i r_j}\right)
The degrees of freedom are calculated as described in equation 6 of the same paper.
References
Nedelman JR, Jia X. An extension of Satterthwaite’s approximation applied to pharmacokinetics. Journal of Biopharmaceutical Statistics. 1998;8(2):317-328. doi:10.1080/10543409808835241
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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