Optimization of clone positions and proportion of mutations in each clone followed by filtering on most likely possibility for each mutation and a re-optimization. Then gives out the possibility with maximal likelihood Relies on foreach
1 2 3 | parallelEM(Schrod, nclust, epsilon, contamination, prior_center = NULL,
prior_weight = NULL, Initializations = 1, optim = "default",
keep.all.models = FALSE)
|
Schrod |
A list of dataframes (one for each sample), generated by the Patient_schrodinger_cellularities() function. |
nclust |
Number of clones to look for (mandatory if prior_center or prior_weight are null) |
epsilon |
Stopping condition for the algorithm: what is the minimal tolerated difference of position or weighted between two steps |
contamination |
Numeric vector with the fraction of normal cells contaminating the sample |
prior_center |
Clone coordinates (from another analysis) to be used |
prior_weight |
Prior on the fraction of mutation in each clone |
Initializations |
Maximal number of independant initial condition tests to be tried |
optim |
use L-BFS-G optimization from R ("default"), or from optimx ("optimx"), or Differential Evolution ("DEoptim") |
keep.all.models |
Should the function output the best model (default; FALSE), or all models tested (if set to true) |
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