<br><br>In this study three isogenic lines of <i>P. falciparum</i> (106/1K76, 106/176I, and 106/76I-352K) were compared to each other with or without CQ treatment (3-hours, 3 biological replicas). The Affymetric Gene Chip was used to generate gene expression profiles. <br>
For this study the parental line is 106/1K76. <br>
For further details please refer to the original publication:<br>
<a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=Pubmed&term=18575593[UID]">Jiang H, Patel JJ, Yi M, Mu J, Ding J, Stephens R, Cooper RA, Ferdig MT, Su XZ. Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene. PLoS One 2008 Jun 25;3(6):e2484</a>.
su_cq_comparisons |
Select a Comparison |
confidence |
PaGE reports 1 - False Discovery Rate (FDR), which is called the "confidence" for the predictions. The FDR of a set of predictions is the expected percent of false predictions in the set of predictions. For example if the algorithm returns 100 genes with a false discovery rate of .3 (confidence=0.7) then we should expect 70 of them to be correct. |
fold_change |
Enter a non-negative number. NOTE: Fold change is reported in the summary as positive numbers for up-regulated genes and negative numbers for down-regulated genes |
regulated_dir |
For ConditionA vs. ConditionB, select up-regulated for genes where ConditionA > ConditionB and select down-regulated for genes where ConditionB > ConditionA. |
o-fields |
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o-tables |
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.convert |
a logical value or a function that controls how the result of the method is returned. If this is a function, the character string or raw vector is passed to this function and it converts it appropriately. If this is a logical value and |
.url |
the URL for the Web request. This defaults to the correct value, but can be specified by the caller if the method is available at a different URL, e.g. locally or in a mirror server. |
.json |
a logical value controlling whether to use the JSON or the XML version of the method |
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