fixAge: project Horvath-type 'epigenetic clock' raw output onto...
In ttriche/biscuitEater: a bunch of convenience functions for Biscuit
Description
Usage
Arguments
Details
Value
Description
The 'Epigenetic Clock' (Horvath 2012) and similar schemes use a number of
CpG loci (or regions, or perhaps CpH loci – it doesn't really matter what)
to estimate the chronological/biological age of samples from DNA methylation
with pre-trained feature weights (coefficients) for each region/locus.
Usage
1
fixAge(x, adult = 21)
Arguments
x
untransformed or raw prediction(s)
adult
age of adulthood (default is 21)
Details
All of these type of clocks use a nonlinear output transformation which
switches from an exponential growth model for children into a linear model
for adults, where adult is an arbitrary number (by default and custom,
that number is 21; elsewhere it can sometimes be seen as 20, but all known
epi-age transformation functions quietly add 1 to the constant internally).
This function implements the above standard output transformation step.
Value
1
transformed prediction(s)
ttriche/biscuitEater documentation built on May 15, 2019, 4:18 p.m.
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Description Usage Arguments Details Value
Description
The 'Epigenetic Clock' (Horvath 2012) and similar schemes use a number of CpG loci (or regions, or perhaps CpH loci – it doesn't really matter what) to estimate the chronological/biological age of samples from DNA methylation with pre-trained feature weights (coefficients) for each region/locus.
Usage
1 | fixAge(x, adult = 21)
|
Arguments
x |
untransformed or raw prediction(s) |
adult |
age of adulthood (default is 21) |
Details
All of these type of clocks use a nonlinear output transformation which
switches from an exponential growth model for children into a linear model
for adults, where adult is an arbitrary number (by default and custom,
that number is 21; elsewhere it can sometimes be seen as 20, but all known
epi-age transformation functions quietly add 1 to the constant internally).
This function implements the above standard output transformation step.
Value
1 | transformed prediction(s)
|
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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