Man pages for 0liver0815/onc-crmpack-test
Object-Oriented Implementation of CRM Designs

AllModels-class'AllModels'
and-StoppingAll-Stopping-methodThe method combining a stopping list and an atomic
and-Stopping-StoppingAll-methodThe method combining an atomic and a stopping list
and-Stopping-Stopping-methodThe method combining two atomic stopping rules
approximateApproximate posterior with (log) normal distribution
BayDesignInitialization function for "Design"
BayDesign-classClass for the Bayer CRM design
biomLevelCompute the biomarker level for a given dose, given model and...
CohortSize-classThe virtual class for cohort sizes
CohortSizeConstInitialization function for "CohortSizeConst"
CohortSizeConst-classConstant cohort size
CohortSizeDLTInitialization function for "CohortSizeDLT"
CohortSizeDLT-classCohort size based on number of DLTs
CohortSizeMaxInitialization function for "CohortSizeMax"
CohortSizeMax-classSize based on maximum of multiple cohort size rules
CohortSizeMinInitialization function for "CohortSizeMin"
CohortSizeMin-classSize based on minimum of multiple cohort size rules
CohortSizePartsInitialization function for "CohortSizeParts"
CohortSizeParts-classCohort size based on the parts
CohortSizeRangeInitialization function for "CohortSizeRange"
CohortSizeRange-classCohort size based on dose range
crmPackExampleOpen the example pdf for crmPack
crmPackHelpOpen the browser with help pages for crmPack
crmPack-packageObject-oriented implementation of CRM designs
DADesignInitialization function for 'DADesign'
DADesign-classClass for the time-to-DLT augmented CRM design
DALogisticLogNormalInitialization function for the 'DALogisticLogNormal' class
DALogisticLogNormal-classLogistic model with bivariate (log) normal prior and data...
dapplyApply a Function to Subsets of Data Frame.
DASimulationsInitialization function for 'DASimulations'
DASimulations-classClass for the simulations output from DA based designs
Data-class'Data'
DataDA-class'DataDA'
DataDual-class'DataDual'
DataMixture-class'DataMixture'
DataParts-class'DataParts'
DesignInitialization function for "Design"
Design-classClass for the CRM design
dinvGammaCompute the density of Inverse gamma distribution
DLTLikelihoodLikelihood of DLTs in each interval
doseComputing the Doses for a Given Probability, Model and...
doseFunctionGetting the Dose Function for a Given Model Type
DualDesignInitialization function for "DualDesign"
DualDesign-classClass for the dual-endpoint CRM design
DualEndpointInitialization function for the "DualEndpoint" class
DualEndpointBetaInitialization function for the "DualEndpointBeta" class
DualEndpointBeta-classDual endpoint model with beta function for dose-biomarker...
DualEndpoint-classGeneral class for the dual endpoint model
DualEndpointEmaxInitialization function for the "DualEndpointEmax" class
DualEndpointEmax-classDual endpoint model with emax function for dose-biomarker...
DualEndpointOld-classDual endpoint model
DualEndpointRWInitialization function for the "DualEndpointRW" class
DualEndpointRW-classDual endpoint model with RW prior for biomarker
DualResponsesDesignInitialization function for 'DualResponsesDesign"
DualResponsesDesign-classThis is a class of design based on DLE responses using the...
DualResponsesSamplesDesignInitialization function for 'DualResponsesSamplesDesign"
DualResponsesSamplesDesign-classThis is a class of design based on DLE responses using the...
DualSimulationsInitialization function for "DualSimulations"
DualSimulations-classClass for the simulations output from dual-endpoint model...
DualSimulationsSummary-classClass for the summary of dual-endpoint simulations output
EffFlexiInitialization function for the "EffFlexi" class
EffFlexi-classClass for the efficacy model in flexible form for prior...
EffloglogInitialization function for the "Effloglog" class
Effloglog-classClass for the linear log-log efficacy model using pseudo data...
enable_loggingVerbose Logging
examineObtain hypothetical trial course table for a design
ExpEffCompute the expected efficacy based on a given dose, a given...
fitFit method for the Samples class
fitGainGet the fitted values for the gain values at all dose levels...
fitPEMGet the fitted DLT free survival (piecewise exponential...
FractionalCRM-classFractional CRM following paper and code by Guosheng Yin et al
gainCompute the gain value with a given dose level, given a...
GeneralData-class'GeneralData'
GeneralModel-class'GeneralModel'
GeneralSimulationsInitialization function for "GeneralSimulations"
GeneralSimulationsBayInitialization function for "GeneralSimulations"
GeneralSimulationsBay-classGeneral class for the simulations output Bayer
GeneralSimulations-classGeneral class for the simulations output
GeneralSimulationsSummaryBay-classClass for the summary of general simulations output
GeneralSimulationsSummary-classClass for the summary of general simulations output
getEffExtracting Efficacy Responses for Subjects Categorized by the...
getMinInfBetaGet the minimal informative unimodal beta distribution
getResultListHelper function to obtain simulation results list
get-Samples-character-methodGet specific parameter samples and produce a data.frame
h_all_equivalentComparison with Numerical Tolerance and Without Name...
h_check_fun_formalsChecking Formals of a Function
h_format_numberConditional Formatting Using C-style Formats
h_is_positive_definiteTesting Matrix for Positive Definiteness
h_jags_add_dummyAppending a Dummy Number for Selected Slots in Data
h_jags_extract_samplesExtracting Samples from 'JAGS' 'mcarray' Object
h_jags_get_dataGetting Data for 'JAGS'
h_jags_get_model_initsSetting Initial Values for 'JAGS' Model Parameters
h_jags_join_modelsJoining 'JAGS' Models
h_jags_write_modelWriting JAGS Model to a File
h_null_if_naGetting 'NULL' for 'NA'
h_null_if_scalarGetting 'NULL' for scalar object
h_plot_data_cohort_linesPreparing Cohort Lines for Data Plot
h_plot_data_dfPreparing Data for Plotting
h_rapplyRecursively Apply a Function to a List
h_slotsGetting the Slots from a S4 Object
h_validate_combine_resultsCombining S4 Class Validation Results
IncrementMinInitialization function for "IncrementMin"
IncrementMin-classMax increment based on minimum of multiple increment rules
IncrementMinDLT1N1Initialization function for "IncrementMinDLT1N1"
IncrementMinDLT1N1-classMax increment based on minimum of multiple increment rules
IncrementsAbsoluteMaxInitialization function for "IncrementsAbsoluteMax"
IncrementsAbsoluteMax-classIncrements control based on absolute differences in intervals
Increments-classThe virtual class for controlling increments
IncrementsHSRBeta-class'IncrementsHSRBeta'
IncrementsHSRBeta_dkInitialization function for "IncrementsHSRBeta_dk"
IncrementsHSRBeta_dk-classIncrements control based on eligable dose levels according to...
IncrementsNlastDLInitialization function for "IncrementsRelativeDLT"
IncrementsNlastDL-classIncrements control based on relative differences in terms of...
IncrementsNumDoseLevelsBaySafetyFixInitialization function for "IncrementsRelativeSafetyFix"
IncrementsNumDoseLevelsBaySafetyFix-classIncrements control based the maximum dose level increase (not...
IncrementsNumDoseLevels-class'IncrementsNumDoseLevels'
IncrementsRelativeInitialization function for "IncrementsRelative"
IncrementsRelative-classIncrements control based on relative differences in intervals
IncrementsRelativeDLTInitialization function for "IncrementsRelativeDLT"
IncrementsRelativeDLT-classIncrements control based on relative differences in terms of...
IncrementsRelativeDLTmaxInitialization function for "IncrementsRelativeDLTmax"
IncrementsRelativeDLTmax-classIncrements control based on relative differences in terms of...
IncrementsRelativeMaxInitialization function for "IncrementsRelative"
IncrementsRelativeMax-classIncrements control based on relative differences in intervals
IncrementsRelativePartsInitialization function for "IncrementsRelativeParts"
IncrementsRelativeParts-classIncrements control based on relative differences in...
IncrementsRelativeSafetyInitialization function for "IncrementsRelativeSafety"
IncrementsRelativeSafety-classIncrements control based on relative safety
IncrementsRelativeSafetyFixInitialization function for "IncrementsRelativeSafetyFix"
IncrementsRelativeSafetyFix-classIncrements control based on relative safety
IncrementsSafetyStopInitialization function for "IncrementsSafetyStop"
IncrementsSafetyStop-classIncrements control based on the number of observed DLTs This...
IncrementsSafetyStopFixInitialization function for "IncrementsSafetyStopFix"
IncrementsSafetyStopFix-classIncrements control based on the number of observed DLTs This...
initialize-DualEndpointOld-methodInitialization method for the "DualEndpointOld" class
is.boolPredicate checking for a boolean option
is.probabilityPredicate checking for a probability
is.probRangePredicate checking for a probability range
is.rangePredicate checking for a numeric range
is.scalarChecking for scalar
is.wholenumberchecks for whole numbers (integers)
LogisticIndepBetaIntialization function for "LogisticIndepBeta" class
LogisticIndepBeta-classNo initialization function Standard logistic model with prior...
LogisticKadaneInitialization function for the "LogisticKadane" class
LogisticKadane2Initialization function for the "LogisticKadane2" class
LogisticKadane2-classReparametrized logistic model (version 2)
LogisticKadaneBayerInitialization function for the "LogisticKadaneBayer" class
LogisticKadaneBayer-classStandard Kadane model
LogisticKadane-classReparametrized logistic model
LogisticLogNormal-class'LogisticLogNormal'
LogisticLogNormalMixtureInitialization function for the "LogisticLogNormalMixture"...
LogisticLogNormalMixture-classStandard logistic model with online mixture of two bivariate...
LogisticLogNormalSub-class'LogisticLogNormalSub'
LogisticNormal-class'LogisticNormal'
LogisticNormalFixedMixtureInitialization function for the "LogisticNormalFixedMixture"...
LogisticNormalFixedMixture-classStandard logistic model with fixed mixture of multiple...
LogisticNormalMixtureInitialization function for the "LogisticNormalMixture" class
LogisticNormalMixture-classStandard logistic model with flexible mixture of two...
logitShorthand for logit function
matchToleranceHelper function for value matching with tolerance
maxDoseDetermine the maximum possible next dose
maxSize"MAX" combination of cohort size rules
mcmcObtaining Posterior Samples for all Model Parameters
McmcOptions-class'McmcOptions'
MinimalInformativeConstruct a minimally informative prior
minSize"MIN" combination of cohort size rules
Model-class'Model'
ModelEff-classNo Initialization function class for Efficacy models using...
ModelLogNormal-class'ModelLogNormal'
ModelPseudo-classClass of models using expressing their prior in form of...
ModelTox-classNo intialization function Class for DLE models using pseudo...
multiplotMultiple plot function
myBarplotConvenience function to make barplots of percentages
myBayesLogitDo MCMC sampling for Bayesian logistic regression model
nextBestFind the next best dose
NextBest-classThe virtual class for finding next best dose
NextBestDualEndpointInitialization function for "NextBestDualEndpoint"
NextBestDualEndpoint-classThe class with the input for finding the next dose based on...
NextBestKadaneBayInitialization function for class "NextBestKadaneBay"
NextBestKadaneBay-classThe class with the input for finding the next best MTD...
NextBestMaxGainInitialization function for the class 'NextBestMaxGain'
NextBestMaxGain-classNext best dose with maximum gain value based on a pseudo DLE...
NextBestMaxGainSamplesInitialization function for class "NextBestMaxGainSamples"
NextBestMaxGainSamples-classNext best dose with maximum gain value based on a pseudo DLE...
NextBestMinDistInitialization function for class "NextBestMinDist"
NextBestMinDist-classClass for Next Best Dose based on Minimum Distance to Target...
NextBestMTDInitialization function for class "NextBestMTD"
NextBestMTD-classThe class with the input for finding the next best MTD...
NextBestMTDCRMInitialization function for class "NextBestMTDCRM"
NextBestMTDCRM-classThe class with the input for finding the next best dose based...
NextBestMTDprobInitialization function for class "NextBestMTDprob"
NextBestMTDprob-classThe class with the input for finding the next best MTD...
NextBestNCRMInitialization function for "NextBestNCRM"
NextBestNCRM-classThe class with the input for finding the next dose in target...
NextBestTDInitialization function for the class "NextBestTD"
NextBestTD-classNext best dose based on Pseudo DLE model without sample
NextBestTDsamplesInitialization function for class "NextBestTDsamples"
NextBestTDsamples-classNext best dose based on Pseudo DLE Model with samples
NextBestThreePlusThreeInitialization function for "NextBestThreePlusThree"
NextBestThreePlusThree-classThe class with the input for finding the next dose in target...
NextBestTwoParBayInitialization function for class "NextBestTwoParBay"
NextBestTwoParBay-classThe class with the input for finding the next best MTD...
noOverlapCheck overlap of two character vectors
OneParExpInitialization function for the "OneParExp" class
OneParExp-classStandard one parameter model
OneParExpNormalPrior-classCRM Model with Skeleton Prior Probabilities
or-StoppingAny-StoppingThe method combining an atomic and a stopping list
or-Stopping-StoppingThe method combining two atomic stopping rules
or-Stopping-StoppingAnyThe method combining a stopping list and an atomic
pinvGammaCompute the distribution function of Inverse gamma...
plot-DataDA-missing-methodPlot Method for the 'DataDA' Class
plot-DataDual-missing-methodPlot Method for the 'DataDual' Class
plot-DataDual-ModelEff-methodPlot of the fitted dose-efficacy based with a given pseudo...
plot-Data-missing-methodPlot Method for the 'Data' Class
plot-Data-ModelTox-methodPlot of the fitted dose-tox based with a given pseudo DLE...
plotDualResponsesPlot of the DLE and efficacy curve side by side given a DLE...
plot-DualSimulations-missing-methodPlot dual-endpoint simulations
plot-DualSimulationsSummary-missing-methodPlot summaries of the dual-endpoint design simulations
plotGainPlot the gain curve in addition with the dose-DLE and...
plot-GeneralSimulations-missing-methodPlot simulations
plot-GeneralSimulationsSummary-missing-methodGraphical display of the general simulation summary
plot.gtablePlots gtable objects
plot-PseudoDualFlexiSimulations-missing-methodThis plot method can be applied to...
plot-PseudoDualSimulations-missing-methodPlot simulations
plot-PseudoDualSimulationsSummary-missing-methodPlot the summary of Pseudo Dual Simulations summary
plot-PseudoSimulationsSummary-missing-methodPlot summaries of the pseudo simulations
plot-Samples-DALogisticLogNormal-methodPlotting dose-toxicity model fits
plot-Samples-DualEndpoint-methodPlotting dose-toxicity and dose-biomarker model fits
plot-Samples-ModelEff-methodPlot the fitted dose-efficacy curve using a model from...
plot-Samples-Model-methodPlotting dose-toxicity model fits
plot-Samples-ModelTox-methodPlot the fitted dose-DLE curve using a 'ModelTox' class model...
plot-SimulationsSummary-missing-methodPlot summaries of the model-based design simulations
printVignetteTaken from utils package (print.vignette)
probComputing Toxicity Probabilities for a Given Dose, Model and...
probFunctionGetting the Prob Function for a Given Model Type
probitShorthand for probit function
ProbitLogNormal-class'ProbitLogNormal'
ProbitLogNormalRel-class'ProbitLogNormalRel'
PseudoDualFlexiSimulationsInitialization function for 'PseudoDualFlexiSimulations'...
PseudoDualFlexiSimulations-classThis is a class which captures the trial simulations design...
PseudoDualSimulationsInitialization function for 'DualPseudoSimulations' class
PseudoDualSimulations-classClass 'PseudoDualSimulations'
PseudoDualSimulationsSummary-classClass for the summary of the dual responses simulations using...
PseudoSimulationsInitialization function of the 'PseudoSimulations' class
PseudoSimulations-classClass 'PseudoSimulations'
PseudoSimulationsSummary-classClass for the summary of pseudo-models simulations output
qinvGammaCompute the quantile function of Inverse gamma distribution
Quantiles2LogisticNormalConvert prior quantiles (lower, median, upper) to logistic...
ReportA Reference Class to represent sequentially updated reporting...
rinvGammaThe random generation of the Inverse gamma distribution
RuleDesignInitialization function for "RuleDesign"
RuleDesign-classClass for rule-based designs
safeIntegerSafe conversion to integer vector
SafetyWindow-classThe virtual class for safety window
SafetyWindowConstInitialization function for 'SafetyWindowConst'
SafetyWindowConst-classConstant safety window length
SafetyWindowSizeInitialization function for 'SafetyWindowSize'
SafetyWindowSize-classSafety window length based on cohort size. This class is used...
SamplesInitialization function for "Samples"
Samples-classClass for the MCMC output
sampleSizeComputing the Number of Samples
saveSampleDetermining if this Sample Should be Saved
setSeedHelper function to set and save the RNG seed
show-DualSimulationsSummary-methodShow the summary of the dual-endpoint simulations
show-GeneralSimulationsSummaryBay-methodShow the summary of the simulations
show-GeneralSimulationsSummary-methodShow the summary of the simulations
show-PseudoDualSimulationsSummary-methodShow the summary of Pseudo Dual simulations summary
show-PseudoSimulationsSummary-methodShow the summary of the simulations
show-SimulationsSummary-methodShow the summary of the simulations
simulate-BayDesign-methodSimulate outcomes from a Bayer CRM design
simulate-DADesign-methodSimulate outcomes from a time-to-DLT augmented CRM design...
simulate-Design-methodSimulate outcomes from a CRM design
simulate-DualDesign-methodSimulate outcomes from a dual-endpoint design
simulate-DualResponsesDesign-methodThis is a methods to simulate dose escalation procedure using...
simulate-DualResponsesSamplesDesign-methodThis is a methods to simulate dose escalation procedure using...
simulate-RuleDesign-methodSimulate outcomes from a rule-based design
simulate-TDDesign-methodThis is a methods to simulate dose escalation procedure only...
simulate-TDsamplesDesign-methodThis is a methods to simulate dose escalation procedure only...
SimulationsInitialization function for the "Simulations" class
SimulationsBayInitialization function for the "Simulations" class
SimulationsBay-classClass for the simulations output from model based designs
Simulations-classClass for the simulations output from model based designs
SimulationsSummaryBay-classClass for the summary of model-based simulations output
SimulationsSummary-classClass for the summary of model-based simulations output
sizeDetermine the size of the next cohort
StoppingAllInitialization function for "StoppingAll"
StoppingAll-classStop based on fulfillment of all multiple stopping rules
StoppingAnyInitialization function for "StoppingAny"
StoppingAny-classStop based on fulfillment of any stopping rule
Stopping-class'Stopping'
StoppingCohortsNearDoseInitialization function for "StoppingCohortsNearDose"
StoppingCohortsNearDose-classStop based on number of cohorts near to next best dose
StoppingGstarCIRatioInitialization function for "StoppingGstarCIRatio"
StoppingGstarCIRatio-classStop based on a target ratio, the ratio of the upper to the...
StoppingHardFirstInitialization function for "StoppingHardFirst"
StoppingHardFirst-classHardstopping rule based on the Bin-Beta distribution and not...
StoppingHardFirstFixInitialization function for "StoppingHardFirstFix"
StoppingHardFirstFix-classStopping rule based on the number of observed DLTs at a dose...
StoppingHighestDoseInitialization function for "StoppingHighestDose"
StoppingHighestDose-classStop when the highest dose is reached
StoppingListInitialization function for "StoppingList"
StoppingList-classStop based on multiple stopping rules
StoppingLowestDoseHSRBeta-class'StoppingLowestDoseHSRBeta'
StoppingLowestDoseHSRBeta_DKInitialization function for "StoppingLowestDoseHSRBeta_DK"
StoppingLowestDoseHSRBeta_DK-classStop based on the lowest dose meeting the hard safety...
StoppingMinCohortsInitialization function for "StoppingMinCohorts"
StoppingMinCohorts-classStop based on minimum number of cohorts
StoppingMinPatientsInitialization function for "StoppingMinPatients"
StoppingMinPatients-classStop based on minimum number of patients
StoppingMTDCV-class'StoppingMTDCV'
StoppingMTDdistributionInitialization function for "StoppingMTDdistribution"
StoppingMTDdistributionBayInitialization function for "StoppingMTDdistributionBay"
StoppingMTDdistributionBay-classstopping rule based on the posterior distribution
StoppingMTDdistribution-classStop based on MTD distribution
StoppingPatientsNearDoseInitialization function for "StoppingPatientsNearDose"
StoppingPatientsNearDose2Initialization function for "StoppingPatientsNearDose2"
StoppingPatientsNearDose2-classStop based on number of patients near to next best dose !! No...
StoppingPatientsNearDoseBayInitialization function for "StoppingPatientsNearDose"
StoppingPatientsNearDoseBay-classStop based on number of patients near to next best dose
StoppingPatientsNearDose-classStop based on number of patients near to next best dose
StoppingProbBayInitialization function for "StoppingProbBay"
StoppingProbBay-classStopping rule based on the posterior probability of the full...
StoppingTargetBiomarkerInitialization function for 'StoppingTargetBiomarker'
StoppingTargetBiomarker-classStop based on probability of target biomarker
StoppingTargetProbInitialization function for "StoppingTargetProb"
StoppingTargetProb-classStop based on probability of target tox interval
StoppingTargetProbPatientsNearHighestDoseInitialization function for...
StoppingTargetProbPatientsNearHighestDose-classStop based on number of patients near to next best dose
StoppingTargetProbPatientsNearLowestDoseInitialization function for...
StoppingTargetProbPatientsNearLowestDose-classStop based on number of patients near to next best dose
StoppingTDCIRatioInitialization function for "StoppingTDCIRatio"
StoppingTDCIRatio-classStop based on a target ratio, the ratio of the upper to the...
stopTrialStop the trial?
summary-DualSimulations-methodSummarize the dual-endpoint design simulations, relative to...
summary-GeneralSimulationsBay-methodSummarize the simulations, relative to a given truth
summary-GeneralSimulations-methodSummarize the simulations, relative to a given truth
summary-PseudoDualFlexiSimulations-methodSummary for Pseudo Dual responses simulations given a pseudo...
summary-PseudoDualSimulations-methodSummary for Pseudo Dual responses simulations, relative to a...
summary-PseudoSimulations-methodSummarize the simulations, relative to a given truth
summary-SimulationsBay-methodSummarize the model-based design simulations, relative to a...
summary-Simulations-methodSummarize the model-based design simulations, relative to a...
TDDesignInitialization function for 'TDDesign' class
TDDesign-classDesign class using DLE responses only based on the pseudo DLE...
TDsamplesDesignInitialization function for 'TDsamplesDesign' class
TDsamplesDesign-classThis is a class of design based only on DLE responses using...
ThreePlusThreeDesignCreates a new 3+3 design object from a dose grid
TITELogisticLogNormalInitialization function for the 'TITELogisticLogNormal' class
TITELogisticLogNormal-classStandard logistic model with bivariate (log) normal prior...
TwoParBayInitialization function for the "TwoParBay" class
TwoParBay-classStandard two parameter model
TwoParBaySInitialization function for the "TwoParBayS" class
TwoParBayS-classImplementation of the two parameter logistic model without...
update-DataDA-methodUpdating 'DataDA' Objects
update-DataDual-methodUpdating 'DataDual' Objects
update-Data-methodUpdating 'Data' Objects
update-DataParts-methodUpdating 'DataParts' Objects
update-EffFlexi-methodUpdate method for the 'EffFlexi' Model class. This is a...
update-Effloglog-methodUpdate method for the 'Effloglog' Model class. This is a...
update-LogisticIndepBeta-methodUpdate method for the 'LogisticIndepBeta'Model class. This is...
Validate'Validate'
validate_data_objectsInternal Helper Functions for Validation of 'GeneralData'...
validate_incrementsInternal Helper Functions for Validation of 'Increments'...
validate_mcmcoptions_objectsInternal Helper Functions for Validation of 'McmcOptions'...
validate_model_objectsInternal Helper Functions for Validation of 'AllModels'...
validate_stoppingInternal Helper Functions for Validation of 'Stopping'...
windowLengthDetermine the safety window length of the next cohort
0liver0815/onc-crmpack-test documentation built on Feb. 19, 2022, 12:25 a.m.