VariantSelection_Quantile: VariantSelection_Quantile

In CostaLab/sigurd: Single cell Genotyping Using RNA Data

VariantSelection_Quantile

Description

We get variants of interest using the quantile thresholding. This function is adapted from the Peter van Galen. Source: https://github.com/petervangalen/MAESTER-2021

Usage

VariantSelection_Quantile(
  SE,
  min_coverage = 2,
  quantiles = c(0.1, 0.9),
  thresholds = c(0.1, 0.9),
  min_quality = NULL,
  mean_allele_frequency = 0,
  remove_nocall = FALSE,
  verbose = TRUE
)

Arguments

SE	SummarizedExperiment object.
min_coverage	Minimum coverage needed.
quantiles	The lower and upper quantile you want to use.
thresholds	The VAF thresholds you want to use for the quantiles.
min_quality	The minimum quality you want for the Variants of Interest. Can be ignored by setting it to NULL.
mean_allele_frequency	The minimum mean allele frequency. Default = 0
remove_nocall	Should NoCall cells (consensus = 0) be disregarded during the analysis?
verbose	Should the function be verbose? Default = TRUE

CostaLab/sigurd documentation built on Feb. 10, 2025, 11:08 p.m.