interactionIndex: Compute Interaction Index based on Loewe Additivity

In ybukhman/SynergyScreen: Analyze and simulate synergy screen data

Description

Compute Interaction Index from SynergyExperiment and the matching DRE (dose-response experiment) objects

Usage

interactionIndex(experiment, effect, dre.list, model = "menls")

Arguments

experiment	an object of class SynergyExperiment
effect	fractional effect value, numeric
dre.list	a list of DRE objects
model	name of the model to use (the same model must be present in all dre.list members)

Details

effect value should be between 0 and 1, e.g. 0.5 to compute interaction index at IC50, 0.25 to compute IC25 (25 Corresponding value of the response variable is defined as control.response*(1-effect)

Value

interaction index value, numeric

See Also

SynergyExperiment, DRE

Examples

data(sim15_screen3)
interactionIndex(synergy_experiment(sim15_screen3,"Cpd1-Cpd2"), 0.5, dre_list(sim15_screen3))

ybukhman/SynergyScreen documentation built on May 4, 2019, 2:31 p.m.