computeSynergies: Compute synergy values

In ybukhman/SynergyScreen: Analyze and simulate synergy screen data

Description

Synergy is measured as interaction index. This function computes values of the interaction index for a set effective dose values for each synergy experiment in a screen.

Usage

computeSynergies(object, ...)

## S4 method for signature 'SynergyScreen'
computeSynergies(object, effect = c(0.25, 0.5,
  0.75), model = "menls", control.weight = 10, span = 1, silent = T,
  ...)

Arguments

object	object of class SynergyScreen
...	other arguments passed to the model-fitting function, e.g. to loess or nls
effect	numeric vector of effects, between 0 and 1
model	character vector of model types. Supported types include melm, menls and loess
control.weight	weight to assing to the control.response, numeric
span	span parameter for loess, numeric
silent	logical: should warnings and error messages be suppressed?

Details

See description of model types in fit

Value

A SynergyScreen object with @synergies slot populated by a data frame of interaction index values

Methods (by class)

• SynergyScreen: Compute synergies in a screen

See Also

SynergyScreen

Examples

data(sim15_screen3)
sim15_screen3 = computeSynergies(sim15_screen3)
synergy_data(sim15_screen3)

ybukhman/SynergyScreen documentation built on May 4, 2019, 2:31 p.m.