kersplatEstBCV: Estimate Kersplat BCV parameters
In Oshlack/splatter: Simple Simulation of Single-cell RNA Sequencing Data

kersplatEstBCV

R Documentation

Estimate Kersplat BCV parameters

Description

Estimate Biological Coefficient of Variation (BCV) parameters for the Kersplat simulation

Usage

kersplatEstBCV(counts, params, verbose)

Arguments

`counts`	counts matrix.
`params`	KersplatParams object to store estimated values in.
`verbose`	logical. Whether to print progress messages

Details

The estimateDisp function is used to estimate the common dispersion across the dataset. An exponential correction is applied based on fitting an exponential relationship between simulated and estimated values. If this results in a negative dispersion a simpler linear correction is applied instead.