kersplatEstLib: Estimate Kersplat library size parameters

In Oshlack/splatter: Simple Simulation of Single-cell RNA Sequencing Data

Estimate Kersplat library size parameters

Description

Estimate the library size parameters for the Kersplat simulation

Usage

kersplatEstLib(counts, params, verbose)

Arguments

counts	counts matrix.
params	KersplatParams object to store estimated values in.
verbose	logical. Whether to print progress messages

Details

Parameters for the log-normal distribution are estimated by fitting the library sizes using fitdist. All the fitting methods are tried and the fit with the best Cramer-von Mises statistic is selected. The density of the library sizes is also estimated using density.

Value

KersplatParams object with library size parameters

Oshlack/splatter documentation built on Dec. 10, 2024, 3:48 p.m.