meffil.cell.type.specific.methylation: Reduce methylation profiles to most cell-type specific sites

In perishky/meffil: Efficient algorithms for DNA methylation

Reduce methylation profiles to most cell-type specific sites

Description

Reduce methylation profiles to most cell-type specific sites

Usage

meffil.cell.type.specific.methylation(
  beta,
  cell.types,
  number.sites = 50,
  verbose = F
)

Arguments

beta	Numeric matrix (values = 0..1; rows = CpG sites; columns = samples).
cell.types	Name of cell type for each column of beta.
number.sites	For each cell type, the number of sites less methylated and the number more methylated than other cell types to include in the reduced methylation profiles.

Value

Numeric matrix (values = 0..1; rows = CpG sites; columns = cell types) with number.sites CpG sites per cell type more methylated than other cell types and the same number less methylated. Values are the mean CpG site methylation levels of all original samples of the same cell type.#

perishky/meffil documentation built on March 20, 2024, 1:56 a.m.