get_multi_tissue_eqtls: Get Multi Tissue Eqtls

In gtexr: Query the GTEx Portal API

Get Multi Tissue Eqtls

Description

Find multi-tissue eQTL Metasoft results.

• This service returns multi-tissue eQTL Metasoft results for a given gene and variant in a specified dataset.

• A Versioned GENCODE ID must be provided.

• For each tissue, the results include: m-value (mValue), normalized effect size (nes), p-value (pValue), and standard error (se).

• The m-value is the posterior probability that an eQTL effect exists in each tissue tested in the cross-tissue meta-analysis (Han and Eskin, PLoS Genetics 8(3): e1002555, 2012).

• The normalized effect size is the slope of the linear regression of normalized expression data versus the three genotype categories using single-tissue eQTL analysis, representing eQTL effect size.

• The p-value is from a t-test that compares observed NES from single-tissue eQTL analysis to a null NES of 0.

By default, the service queries the latest GTEx release. The retrieved data is split into pages with items_per_page entries per page

GTEx Portal API documentation

Usage

get_multi_tissue_eqtls(
  gencodeIds,
  variantId = NULL,
  datasetId = "gtex_v8",
  page = 0,
  itemsPerPage = 250
)

Arguments

gencodeIds	A character vector of Versioned GENCODE IDs, e.g. c("ENSG00000132693.12", "ENSG00000203782.5").
variantId	String. A gtex variant ID.
datasetId	String. Unique identifier of a dataset. Usually includes a data source and data release. Options: "gtex_v8", "gtex_snrnaseq_pilot".
page	Integer (default = 0).
itemsPerPage	Integer (default = 250).

Value

A tibble.

See Also

Other Static Association Endpoints: get_eqtl_genes(), get_fine_mapping(), get_independent_eqtl(), get_significant_single_tissue_eqtls(), get_significant_single_tissue_eqtls_by_location(), get_significant_single_tissue_ieqtls(), get_significant_single_tissue_isqtls(), get_significant_single_tissue_sqtls(), get_sqtl_genes()

Examples

## Not run: 
# search by gene
get_multi_tissue_eqtls(gencodeId = c("ENSG00000132693.12",
                                     "ENSG00000203782.5"))

## End(Not run)

gtexr documentation built on Sept. 19, 2024, 5:06 p.m.