splatPopSimMeans: Simulate mean gene expression matrix without eQTL effects

In Oshlack/splatter: Simple Simulation of Single-cell RNA Sequencing Data

Simulate mean gene expression matrix without eQTL effects

Description

Gene mean expression levels are assigned to each gene for each pair randomly from a normal distribution parameterized using the mean and cv assigned to each gene in the key. If gene means matrix is provided, those will be used instead.

Usage

splatPopSimMeans(vcf, key, means)

Arguments

vcf	VariantAnnotation object containing genotypes of samples.
key	Partial splatPop key data.frame.
means	Null or matrix of gene means to use

Value

matrix of gene mean expression levels WITHOUT eQTL effects.

Oshlack/splatter documentation built on Nov. 15, 2024, 7:25 p.m.