Description Usage Arguments Details Value Examples

The function takes a `SigSet`

as input, computes detection p-value
using negative control probes parametrized in a normal distribution and
returns a new `SigSet`

with an updated pval slot.

1 2 3 4 5 6 7 8 | ```
detectionPfixedNorm(
sset,
muG = 500,
sdG = 200,
muR = 500,
sdR = 200,
force = FALSE
)
``` |

`sset` |
a |

`muG` |
mean of background in Grn channel |

`sdG` |
SD of background in Grn channel |

`muR` |
mean of background in Red channel |

`sdR` |
SD of background in Red channel |

`force` |
force rerun even if result already exists |

Background of Grn and Red are estimated separately from a fixed normal distribution. p-value is taken from the minimum of the p-value of the two alleles (color depends on probe design).

detection p-value

1 2 | ```
sset <- makeExampleSeSAMeDataSet()
sset <- detectionPfixedNorm(sset)
``` |

sesame documentation built on Nov. 15, 2020, 2:08 a.m.

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