detectionPfixedNorm: Detection P-value based on normal fitting with gived...
In sesame: Tools For Analyzing Illumina Infinium DNA Methylation Arrays

Description Usage Arguments Details Value Examples

The function takes a SigSet as input, computes detection p-value using negative control probes parametrized in a normal distribution and returns a new SigSet with an updated pval slot.

detectionPfixedNorm(
  sset,
  muG = 500,
  sdG = 200,
  muR = 500,
  sdR = 200,
  force = FALSE
)

`sset`	a `SigSet`
`muG`	mean of background in Grn channel
`sdG`	SD of background in Grn channel
`muR`	mean of background in Red channel
`sdR`	SD of background in Red channel
`force`	force rerun even if result already exists

Background of Grn and Red are estimated separately from a fixed normal distribution. p-value is taken from the minimum of the p-value of the two alleles (color depends on probe design).

detection p-value