cubeXShredderMF: Inheritance Cube: Autosomal X-Shredder

In MGDrivE: Mosquito Gene Drive Explorer

Inheritance Cube: Autosomal X-Shredder

Description

This function creates an inheritance cube to model an autosomal X-Shredder construct. This construct resides on an autosomal chromosome, and chops the X chromosome into many pieces during gametogenesis, destroying the X chromosome. Thus, males may only produce Y gametes and females can become sterile.
This drive has 2 loci:

• Locus 1, the autosomal locus, has 3 alleles:

  • W: Wild-type allele

  • A: Attacking allele, contains the shredder construct

  • B: Broken attacking allele, shredder construct is defunct

• Locus 2, the sex locus, has 3 alleles:

  • X: Wild-type X allele

  • R: X-allele resistant to cleavage

  • Y: Wild-type Y allele

Usage

cubeXShredderMF(
  cM = 1,
  cF = 1,
  crM = 0,
  crF = 0,
  cbM = 0,
  cbF = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cM	Rate of X shredding in males (default is 1, complete shredding)
cF	Rate of X shredding in females (default is 1, complete shredding)
crM	Rate of resistance chromosome generation in males (default is 0)
crF	Rate of resistance chromosome generation in females (default is 0)
cbM	Rate of shredder construct breakdown in males (default is 0)
cbF	Rate of shredder construct breakdown in females (default is 0)
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Sept. 9, 2025, 5:42 p.m.