directed_nes: Computes the Directed NES

In califano-lab/PISCES: Protein Activity Inferecne in Single Cells

Computes the Directed NES

Description

Computes the Directed NES

Usage

directed_nes(R, S, AW.AM.prod, E.rs, E.r2, n)

Arguments

R	Rank normalized ges matrix (genes x samples).
S	Sign of ges matrix (genes x samples).
AW.AM.prod	Product of the association weight (AW) and mode (AM) matrices created from the regulon list.
E.rs	Expected value of r*s in each sample (1 x samples).
E.r2	Expected value of r^2 in each sample (scalar value).
n	Number of samples (scalar value).

Value

List of matrices, each (regulons x samples): Enrichment score matrix 'es'; expected value 'exp'; variance 'var'; NES matrix 'NES'

califano-lab/PISCES documentation built on Jan. 11, 2023, 5:34 a.m.