# A + B Escalation Design without Dose De-escalation

### Description

The general A+B designs without dose de-escalation. There are A patients at dose level i.

(1) If less than C/A patients have dose limiting toxicity (DLTs), then the dose is escalated to the next dose level i+1.

(2)If more than D/A (D *≥* C) patients have DLTs, then the previous dose i-1 will be considered the maximum tolerable dose (MTD).

(3)If no less than C/A but no more than D/A patients have DLTs, B more patients are treated at this dose level i.

(4)If no more than E (where E *≥* D) of the total A+B patients have DLT, then the dose is escalated.

(5)If more than E of the total of A+B patients have DLT, then the previous dose i-1 will be considered the MTD.

### Usage

1 | ```
AB.withoutDescalation(A, B, C, D, E, DLT)
``` |

### Arguments

`A` |
number of patients for the start A |

`B` |
number of patients for the continuous B |

`C` |
number of patients for the first cut off C |

`D` |
number of patients for the second cut off D, D |

`E` |
number of patients for the third cut off D, E |

`DLT` |
dose limiting toxicity rate for each dose level. |

### References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

### Examples

1 2 3 4 | ```
DLT=c(0.01,0.014,0.025,0.056,0.177,0.594,0.963)
Example.11.6.1<-AB.withoutDescalation(A=3,B=3,C=1,D=1,E=1,DLT=DLT)
Example.11.6.1
# Example.11.6.1[1]=3.1
``` |