MeanWilliamsDesign.Equivalence: Test for Equivalence in Multiple-Sample William Design

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Description

Compare more than two treatment under a crossover design.

H0: |margin| ≥ δ Ha: |margin| < δ

This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha

Usage

MeanWilliamsDesign.Equivalence(alpha, beta, sigma, k, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
sigma	standard deviation
k	Total k treatments in the design
delta	the superiority or non-inferiority margin
margin	margin=μ_i-μ_j the difference between the true mean response of group i μ_i and group j μ_j

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

TrialSize documentation built on July 8, 2020, 7:19 p.m.