Description Usage Arguments References
View source: R/MeanWilliamsDesign.Equivalence.R
Compare more than two treatment under a crossover design.
H0: |margin| ≥ δ Ha: |margin| < δ
This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha
1 | MeanWilliamsDesign.Equivalence(alpha, beta, sigma, k, delta, margin)
|
alpha |
significance level |
beta |
power = 1-beta |
sigma |
standard deviation |
k |
Total k treatments in the design |
delta |
the superiority or non-inferiority margin |
margin |
margin=μ_i-μ_j the difference between the true mean response of group i μ_i and group j μ_j |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
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