Description Usage Arguments References Examples
View source: R/Dose.Response.time.to.event.R
Under the exponential survival model, let lambdai be the proportion hazard rate for group i.
∑ ci = 0.
Ho: L(μ) = ∑ ci \times λ_i =0
Ha: L(p) = ∑ ci \times λ_i = ε > 0
1 | Dose.Response.time.to.event(alpha, beta, T0, T, Ti, ci, fi)
|
alpha |
significance level |
beta |
power = 1-beta |
T0 |
T0 is the accrual time period |
T |
T is the total trial duration |
Ti |
λ_i=log(2)/Ti, Ti is the estimated median time for each group. |
ci |
a linear contrast coefficients ci with sum(ci)=0. |
fi |
fi=ni/n is the sample size fraction for the ith group |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 | Ti=c(14,20,22,24);
ci=c(-6,1,2,3);
Example.11.3.1<-Dose.Response.time.to.event(alpha=0.05,beta=0.2,T0=9,T=16,Ti=Ti,ci=ci,fi=1/4)
Example.11.3.1
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fi1=c(1/9,2/9,2/9,2/9);
Example.11.3.2<-Dose.Response.time.to.event(alpha=0.05,beta=0.2,T0=9,T=16,Ti=Ti,ci=ci,fi=fi1)
Example.11.3.2
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fi2=c(1/2.919,0.711/2.919,0.634/2.919,0.574/2.919);
Example.11.3.3<-Dose.Response.time.to.event(alpha=0.05,beta=0.2,T0=9,T=16,Ti=Ti,ci=ci,fi=fi2)
Example.11.3.3
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