CrossOver.ISV.Equivalence: Test for Similarity of Intra-Subject Variabilities in...

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Test for Similarity of Intra-Subject Variabilities in Crossover Design

Description

the ratio = within-subject variance of treatment T / within-subject variance of treatment R

H0: the ratio \ge \delta or the ratio \le \frac{1}{\delta}

Ha: \frac{1}{\delta} < the ratio < \delta

Usage

CrossOver.ISV.Equivalence(alpha, beta, sigma1, sigma2, m, margin)

Arguments

alpha	significance level
beta	power = 1-beta
sigma1	within-subject variance of treatment 1
sigma2	within-subject variance of treatment 2
m	for each subject, there are m replicates.
margin	margin= \delta, the true ratio of sigma1/sigma2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

TrialSize documentation built on April 12, 2025, 2:01 a.m.