Description Usage Arguments Value References Examples
The most commonly used design for ABE is a standard twosequence and twoperiod crossover design. Ft is the fixed effect of the test formulation and Fr is the fixed effect of the reference formulation.
Ho: FtFr ≤ δ_{L} or FtFr ≤ δ_{U}
Ha: δ_{L} < FtFr < δ_{U}
1 
alpha 
significance level 
beta 
power = 1 beta 
sigma1.1 
σ_{a.b} with a=1 and b=1. 
delta 
delta is the bioequivalence limit. here delta=0.223 
epsilon 
epsilon=FtFr 
σ_{a.b}^{2}=σ_{D}^{2}+a*σ_{WT}^{2}+b*σ_{WR}^{2}
.
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
1 2 3  Example.10.2<ABE(0.05,0.2,0.4,0.223,0.05)
Example.10.2
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