Dose.Response.binary: Linear Contrast Test for Binary Dose Response Study

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Linear Contrast Test for Binary Dose Response Study

Description

pi is the proportion of response in the ith group.

Ho: p1=p2=...=pk

Ha: L(p)= \sum ci \times pi = \epsilon, not equal to 0

Usage

Dose.Response.binary(alpha, beta, pi, ci, fi)

Arguments

alpha	significance level
beta	power = 1-beta
pi	pi is the proportion of response in the ith group.
ci	a linear contrast coefficients ci with \sum ci=0 .
fi	fi=ni/n is the sample size fraction for the ith group

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

pi=c(0.05,0.12,0.14,0.16);
ci=c(-6,1,2,3);

Example.11.2<-Dose.Response.binary(alpha=0.05,beta=0.2,pi=pi,ci=ci,fi=1/4)
Example.11.2
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TrialSize documentation built on April 12, 2025, 2:01 a.m.