MeanWilliamsDesign.NIS: Test for Non-Inferiority/Superiority in Multiple-Sample...

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Test for Non-Inferiority/Superiority in Multiple-Sample William Design

Description

Compare more than two treatment under a crossover design.

H0: margin \le \delta Ha: margin > \delta

if \delta >0, the rejection of Null Hypothesis indicates the superiority of the test over the control;

if \delta <0, the rejection of the null hypothesis implies the non-inferiority of the test against the control.

Usage

MeanWilliamsDesign.NIS(alpha, beta, sigma, k, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
sigma	standard deviation
k	Total k treatments in the design
delta	the superiority or non-inferiority margin
margin	margin=\mu_i-\mu_j the difference between the true mean response of group i \mu_i and group j \mu_j

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

TrialSize documentation built on April 12, 2025, 2:01 a.m.