View source: R/CrossOver.ISV.NIS.R
CrossOver.ISV.NIS | R Documentation |
H0: the ratio that within-subject variance of treatment T / within-subject variance of treatment R \ge \delta
Ha: the ratio < \delta
if \delta
< 1, the rejection of Null Hypothesis indicates the superiority of the test drug over the reference for the intra-subject variability;
if \delta
> 1, the rejection of the null hypothesis implies the non-inferiority of the test drug against the reference for the intra-subject variability; .
CrossOver.ISV.NIS(alpha, beta, sigma1, sigma2, m, margin)
alpha |
significance level |
beta |
power = 1-beta |
sigma1 |
within-subject variance of treatment 1 |
sigma2 |
within-subject variance of treatment 2 |
m |
for each subject, there are m replicates. |
margin |
margin= |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
Example.9.1.1<-CrossOver.ISV.NIS(0.05,0.2,0.3^2,0.45^2,2,1.1)
Example.9.1.1
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.