Description Usage Arguments References Examples

b is the log hazard ratio for treatment, *δ* is the margin

H0: b * ≤ δ *

Ha: b > *δ*

1 |

`alpha` |
significance level |

`beta` |
power = 1-beta |

`loghr` |
log hazard ratio=log(lamda2/lamda1)=b |

`p1` |
the proportion of patients in treatment 1 group |

`p2` |
the proportion of patients in treatment 2 group |

`d` |
the probability of observing an event |

`margin` |
margin is the true difference of log hazard rates between control group lamda1 and a test drug group lamda2 |

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

1 2 |

TrialSize documentation built on May 30, 2017, 7:18 a.m.

Embedding an R snippet on your website

Add the following code to your website.

For more information on customizing the embed code, read Embedding Snippets.