Cox.NIS: Test for non-inferiority/superiority in Cox PH model.

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Test for non-inferiority/superiority in Cox PH model.

Description

b is the log hazard ratio for treatment, \delta is the margin

H0: b \le \delta

Ha: b > \delta

Usage

Cox.NIS(alpha, beta, loghr, p1, d, delta)

Arguments

alpha	significance level
beta	power = 1-beta
loghr	log hazard ratio=log(lamda2/lamda1)=b
p1	the proportion of patients in treatment 1 group
d	the probability of observing an event
delta	margin is the true difference of log hazard rates between control group lamda1 and a test drug group lamda2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.7.3.4<-Cox.NIS(0.05,0.2,log(2),0.5,0.8,0.5)
Example.7.3.4

TrialSize documentation built on April 12, 2025, 2:01 a.m.