Dose.Min.Effect: Williams' Test for Minimum effective dose (MED)

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Description

Ho: μ_1=μ_2=...=μ_K Ha: μ_1=μ_2=...=μ_{i-1} < μ_{i} < μ_{i+1} < μ_{K}

Usage

Dose.Min.Effect(alpha, beta, qt, sigma, delta)

Arguments

alpha	significance level
beta	power = 1-beta
qt	the critical value tk(alpha)
sigma	standard deviation
delta	δ is the clinically meaningful minimal difference

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.11.4.1<-Dose.Min.Effect(0.05,0.2,1.75,0.22,0.11)
Example.11.4.1
#54

Example output

[1] 53.732

TrialSize documentation built on July 8, 2020, 7:19 p.m.