Dose.Min.Effect: Williams' Test for Minimum effective dose (MED)

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Williams' Test for Minimum effective dose (MED)

Description

Ho: \mu_1=\mu_2=...=\mu_K Ha: \mu_1=\mu_2=...=\mu_{i-1} < \mu_{i} < \mu_{i+1} < \mu_{K}

Usage

Dose.Min.Effect(alpha, beta, qt, sigma, delta)

Arguments

alpha	significance level
beta	power = 1-beta
qt	the critical value tk(alpha)
sigma	standard deviation
delta	\delta is the clinically meaningful minimal difference

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.11.4.1<-Dose.Min.Effect(0.05,0.2,1.75,0.22,0.11)
Example.11.4.1
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TrialSize documentation built on April 12, 2025, 2:01 a.m.