Description Usage Arguments References Examples

2 by 2 crossover design. Test the treatment-by-period interaction (carry-over effect)

H0: the difference of the two sequence carry-over effects is equal to 0

Ha: not equal to 0

The test is finding whether there is a difference between the carry-over effect for sequence AB and BA.

1 | ```
Carry.Over(alpha, beta, sigma1, sigma2, gamma)
``` |

`alpha` |
significance level |

`beta` |
power = 1-beta |

`sigma1` |
standard deviation of sequence AB |

`sigma2` |
standard deviation of sequence BA |

`gamma` |
the difference of carry-over effect between sequence AB and BA |

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

1 2 | ```
Example.6.5.2<-Carry.Over(0.025,0.2,2.3,2.4,0.89)
Example.6.5.2 # 110
``` |

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