Description Usage Arguments References

H0: within-subject variance of treatment T is equal to within-subject variance of treatment R

Ha: not equal

The test is finding whether two drug products have the same intra-subject variability.

1 | ```
ISV.Equality(alpha, beta, sigma1, sigma2, m)
``` |

`alpha` |
significance level |

`beta` |
power = 1-beta |

`sigma1` |
within-subject variance of treatment 1 |

`sigma2` |
within-subject variance of treatment 2 |

`m` |
for each subject, there are m replicates. |

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

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