ISV.Equality: Test for Equality of Intra-Subject Variabilities

Description Usage Arguments References

Description

H0: within-subject variance of treatment T is equal to within-subject variance of treatment R

Ha: not equal

The test is finding whether two drug products have the same intra-subject variability.

Usage

1
ISV.Equality(alpha, beta, sigma1, sigma2, m)

Arguments

alpha

significance level

beta

power = 1-beta

sigma1

within-subject variance of treatment 1

sigma2

within-subject variance of treatment 2

m

for each subject, there are m replicates.

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003



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