ISV.Equality: Test for Equality of Intra-Subject Variabilities

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Test for Equality of Intra-Subject Variabilities

Description

H0: within-subject variance of treatment T is equal to within-subject variance of treatment R

Ha: not equal

The test is finding whether two drug products have the same intra-subject variability.

Usage

ISV.Equality(alpha, beta, sigma1, sigma2, m)

Arguments

alpha	significance level
beta	power = 1-beta
sigma1	within-subject variance of treatment 1
sigma2	within-subject variance of treatment 2
m	for each subject, there are m replicates.

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

TrialSize documentation built on April 12, 2025, 2:01 a.m.