ISCV.NIS: Test for Non-Inferiority/Superiority of Intra-Subject CVs

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Test for Non-Inferiority/Superiority of Intra-Subject CVs

Description

H0: CVr - CVt < \delta

Ha: CVr - CVt \ge \delta

if \delta > 0, the rejection of Null Hypothesis indicates the superiority of the test drug over the reference;

if \delta < 0, the rejection of the null hypothesis implies the non-inferiority of the test drug against the reference.

Usage

ISCV.NIS(alpha, beta, CVt, CVr, m, margin)

Arguments

alpha	significance level
beta	power = 1-beta
CVt	Coefficient Of Variation for treatment T
CVr	Coefficient Of Variation for treatment R
m	for each subject, there are m replicates.
margin	margin=delta,

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.9.2.1<-ISCV.NIS(0.05,0.2,0.7,0.5,2,0.1)
Example.9.2.1

TrialSize documentation built on April 12, 2025, 2:01 a.m.